{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:08:01Z","timestamp":1792192081094,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To create a risk scoring system comprised of clinical and radiological characteristics that can predict the likelihood of antibiotic treatment failure of tubo\u2010ovarian abscesses. The score should guide clinicians in identifying patients to whom early intervention should be offered instead of a prolonged trial of antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter, retrospective cohort study carried out between January 1, 2013 and September 30, 2019, identified consecutive patients with tubo\u2010ovarian abscess. Using a chronological split, patients were allocated to two groups for the development and subsequent validation of the postulated scoring system. Univariate and bivariate analyses were performed to identify statistically significant variables for the failure of intravenous antibiotic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 214 consecutive patients with tubo\u2010ovarian abscesses were identified. Data from the first 150 patients were used for the development of the postulated scoring system; data from the subsequent 64 patients were used for validation. Statistically significant clinical features between those having successful and unsuccessful management were: temperature (median\u00a0=\u00a037.1\u2103 vs 38.2\u2103,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.0001), C\u2010reactive protein (151\u00a0mg\/L vs 243\u00a0mg\/L,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.0001), and tubo\u2010ovarian abscess diameter (6.0\u00a0cm vs 8.0\u00a0cm,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.0001). These parameters were used to create a risk prediction score. A score of four or more was predictive of requiring surgical\/radiological intervention of tubo\u2010ovarian abscess (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). The score had a sensitivity of 69% and a specificity of 88%, with area under the curve (AUC)\u00a0=\u00a00.859.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Currently, there is no guidance for clinicians on when to operate on a tubo\u2010ovarian abscess. Our prediction score is simple, using only three easily obtained clinical characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13932","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T15:15:42Z","timestamp":1631891742000},"page":"588-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tubo\u2010ovarian abscess: A proposed new scoring system to guide clinical management"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-0888","authenticated-orcid":false,"given":"Gabriella","family":"Yongue","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology West Middlesex University Hospital  Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Mollier","sequence":"additional","affiliation":[{"name":"Imperial College School of Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheba","family":"Anin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; 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