{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:12:20Z","timestamp":1787875940037,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601276"],"award-info":[{"award-number":["81601276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether the depot gonadotropin\u2010releasing hormone (GnRH) agonist protocol could improve in vitro fertilization (IVF) outcomes for young poor responders from POSEIDON group 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was carried out from June 2017 to June 2020. A total of 451 patients were assigned to three groups depending on the ovarian stimulation protocols. The outcome parameters of IVF were compared in each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients who received the depot GnRH agonist had significantly higher cumulative clinical pregnancy rates (50.88%, 32.02%, and 31.88%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.009 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007) and cumulative live birth rate (48.25%, 26.97%, and 28.99%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.009) compared with mild ovarian stimulation protocol and GnRH antagonist protocol. They also had higher live birth rate per fresh embryo transfer cycle (47.78%, 32.35%, and 36.62%, respectively), but these differences were not statistically significant. Moreover, duration of stimulation, total dose of gonadotropins and endometrial thickness were significantly higher among women who received the depot GnRH agonist (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). However, they had lower embryo transfer cancellation rate, and abnormal endometrium rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The depot GnRH agonist protocol may improve cumulative clinical pregnancy rate and cumulative live birth rate for young women with poor ovarian response from POSEIDON group 3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13933","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T15:15:35Z","timestamp":1631891735000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of the depot gonadotropin\u2010releasing hormone agonist protocol on in vitro fertilization outcomes in young poor ovarian responders from POSEIDON group 3"],"prefix":"10.1002","volume":"157","author":[{"given":"Wenshu","family":"Li","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Yantai Yuhuangding Hospital Affiliated Hospital of Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Yantai Yuhuangding Hospital Affiliated Hospital of Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Yantai Yuhuangding Hospital Affiliated Hospital of Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yantai Yuhuangding Hospital Affiliated Hospital of Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-1625","authenticated-orcid":false,"given":"Xuemei","family":"Liu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Yantai Yuhuangding Hospital Affiliated Hospital of Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00281"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.02.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.03.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.05.026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.03.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-020-00666-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.04.028"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa086"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103210"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1528221"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118816835"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-016-1569-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916447"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2014.40743"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.030"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.09.027"},{"issue":"1","key":"e_1_2_8_19_1","first-page":"CD004635","article-title":"Long\u2010term pituitary down\u2010regulation before in vitro fertilization (IVF) for women with endometriosis","author":"Sallam HN","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00518-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-26"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2017.01.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-007-9164-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.09.028"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90427-Q"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.05.011"}],"container-title":["International Journal of Gynecology &amp; 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