{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:21:03Z","timestamp":1785842463293,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adenocarcinoma in situ (AIS) of the cervix is a premalignant lesion, and a precursor of invasive disease. It is less frequent than its squamous counterpart. During pregnancy, AIS is a scarcely described scenario, whose diagnosis barely differs from non\u2010pregnant patients. Its management is challenging with hysterectomy being the definitive treatment. However, its high incidence in young patients makes fertility\u2010sparing management an approachable option for selected patients. The objective of this study is twofold. Firstly, we describe a case of a patient with AIS during pregnancy and the postpartum period. Secondly, the available literature is reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective medical record review of a single case and a medical literature search in Pubmed of AIS cases in pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 31\u2010year\u2010old woman with cervical AIS diagnosed during pregnancy underwent serial fertility\u2010sparing surgeries including a loop electrosurgical excision procedure and endocervical curettage during the second trimester, and a re\u2010conization and a simple traquelectomy during the postpartum period, until negative margins were achieved. Upon reviewing the literature from 1965 to 2020, 23 other cases were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgical management of cervical AIS during pregnancy is a safe procedure. Subsequent conservative surgeries imply a real challenge to preserve fertility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13948","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T17:38:36Z","timestamp":1632505116000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cervical adenocarcinoma in situ during pregnancy and subsequent fertility\u2010sparing therapy challenge"],"prefix":"10.1002","volume":"158","author":[{"given":"Cristina","family":"S\u00e1nchez\u2010Cuerda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Infanta Sof\u00eda University Hospital San Sebasti\u00e1n de los Reyes  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cuadra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Infanta Sof\u00eda University Hospital San Sebasti\u00e1n de los Reyes  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"G\u00e1mir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Infanta Sof\u00eda University Hospital San Sebasti\u00e1n de los Reyes  Madrid Spain"},{"name":"European University Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Infanta Sof\u00eda University Hospital San Sebasti\u00e1n de los Reyes  Madrid Spain"},{"name":"European University Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Elices","sequence":"additional","affiliation":[{"name":"Department of Pathology Infanta Sof\u00eda University Hospital San Sebasti\u00e1n de los Reyes  Madrid Spain"},{"name":"European University Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Infanta Sof\u00eda University Hospital San Sebasti\u00e1n de los Reyes  Madrid Spain"},{"name":"European University Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199806)18:6<393::AID-DC2>3.0.CO;2-A"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.12.060"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.06.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.07.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20064"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.09.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb04791.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03140220011003"},{"key":"e_1_2_7_10_1","first-page":"223","article-title":"Adenocarcinoma in situ of the endocervix with co\u2010existent intrauterine pregnancy: report of a case and review of literature","volume":"9","author":"Edinger DD","year":"1982","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13047"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-002-0469-2"},{"key":"e_1_2_7_14_1","first-page":"663","article-title":"Adenocarcinoma in situ of the cervix during pregnancy","volume":"54","author":"Matey DA","year":"1979","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.079"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000287"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170587"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.09.053"}],"container-title":["International Journal of Gynecology &amp; 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