{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T13:17:30Z","timestamp":1700140650933},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether serum procalcitonin (PCT) is useful for differentiating acute pyelonephritis (APN) from asymptomatic bacteriuria and acute cystitis during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter prospective observational study was conducted to compare serum white blood cell (WBC) counts, erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP) level, and PCT level among pregnant women with asymptomatic bacteriuria, acute cystitis, and APN and healthy pregnant women (controls). Utility of WBC count, ESR, CRP, and PCT biomarkers for the prediction of APN during pregnancy were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Area under the curve (AUC) values of PCT, CRP, ESR, and WBC count for predicting asymptomatic bacteriuria were 0.576, 0.628, 0.542, and 0.532, respectively; those for predicting acute cystitis were 0.766, 0.735, 0.681, and 0.597, respectively; and those for predicting acute pyelonephritis 0.859, 0.763, 0.711, and 0.732, respectively. Compared with the other inflammatory markers used to predict APN, PCT exhibited the highest AUC (0.859 [95% confidence interval (CI) 0.711\u20130.935]). A cutoff value of &gt;0.25\u00a0ng\/ml had a sensitivity of 87% and a specificity of 79%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum PCT can be a valuable addition to existing methods of differentiating asymptomatic bacteriuria, acute cystitis, and APN during pregnancy and can facilitate the early identification of APN during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13955","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T17:10:52Z","timestamp":1633108252000},"page":"64-69","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum procalcitonin to differentiate acute antepartum pyelonephritis from asymptomatic bacteriuria and acute cystitis during pregnancy: A multicenter prospective observational study"],"prefix":"10.1002","volume":"158","author":[{"given":"Shang\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Chang Gung Memorial Hospital\u2010Linkou Medical Center Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Hua","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Taipei City Hospital  Taipei Taiwan"},{"name":"Department of Biomedical Engineering National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Women and Children\u2019s Hospital Xiamen University  Xiamen Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Ying","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fujian Maternity and Child Health Hospital Affiliated Hospital of Fujian Medical University  Fuzhou Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Jen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chang Gung Memorial Hospital\u2010Linkou Medical Center Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2017.1370579"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102362.2008.02009.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2013.39202"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000149154.96285.a0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.10.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1407244"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/124102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903067378"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009185.pub3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20100711\u201012\u201025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13346"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12907"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2011.082"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12823"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014914"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2019.103488"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010018\u20101349\u20107"}],"container-title":["International Journal of Gynecology &amp; 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