{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:19:36Z","timestamp":1759011576924},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In Japan, no region has introduced primary HPV testing for cervical cancer screening. We assessed the diagnostic value and possible harm of HPV testing in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study with historical controls used cytology\u2010based screening and co\u2010testing data in Japan. As surrogate indicators of possible harm, colposcopy referral rate and cervical intraepithelial neoplasm (CIN) 1 detection rates were calculated. As surrogate indicators with diagnostic values, the detection rates of CIN2 or greater (CIN2+) and CIN3+ were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data of 297\u00a0970 women (182\u00a0697 for cytology\u2010based, 115\u00a0273 for co\u2010testing) were examined. The detection rates of CIN1, CIN2+, and CIN3+ were significantly higher in the co\u2010testing group than in the cytology\u2010based group (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01, respectively). Between ages 25\u201349, CIN2+ detection rates were significantly higher in the co\u2010testing group than in the cytology\u2010based group (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05 for each 5\u2010year age group). Between ages 30\u201349, CIN3+ detection rates were significantly higher in the co\u2010testing group than in the cytology\u2010based group (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05 for each 5\u2010year age group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Limiting the target age group may minimize the possible harm of screening. Cytology\/HPV co\u2010testing may be useful in Japanese populations if balance is maintained between benefit and harm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13961","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T04:36:05Z","timestamp":1633408565000},"page":"187-193","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is cytology\/HPV co\u2010testing for cervical cancer screening useful in Japan?"],"prefix":"10.1002","volume":"158","author":[{"given":"Tetsuro","family":"Oishi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzo","family":"Kigawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Matsue City Hospital  Matsue Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Iwanari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shimane Prefectural Central Hospital  Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuzo","family":"Kasai","sequence":"additional","affiliation":[{"name":"Medical Checkup Center Chiba Foundation for Health Promotion &amp; Disease Prevention  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medical Sciences Fukui University  Eiheiji\u2010cho Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Hamada","sequence":"additional","affiliation":[{"name":"Hamada Ladies Clinic  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Fujita","sequence":"additional","affiliation":[{"name":"Cytology Center Hokkaido Cancer Society  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Sakuragi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasuku","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Tottori University  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Cancer Center Shin\u2010Yurigaoka General Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30482-6"},{"key":"e_1_2_8_3_1","unstructured":"Centre for Cancer Control and Information Services. Cancer statistics in Japan (in Japanese). Accessed March 8 2021.https:\/\/ganjoho.jp\/reg_stat\/statistics\/dl\/index.html"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30121-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30157-4"},{"key":"e_1_2_8_6_1","unstructured":"Centre for Cancer Control and Information Services. Cancer statistics in Japan (in Japanese). Accessed March 8 2021https:\/\/ganjoho.jp\/reg_stat\/statistics\/stat\/screening.html"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70731-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31824ca9d5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.10897"},{"key":"e_1_2_8_10_1","unstructured":"Committee on Cancer Control Japan Association of Obstetricians and Gynecologists. Recommendation for cervical cancer screening 2011 (In Japanese). Accessed March 8 2021.http:\/\/www.cczeropro.jp\/assets\/files\/ikai.pdf"},{"key":"e_1_2_8_11_1","unstructured":"Japanese guideline for cervical cancer screening 2019 (In Japanese). 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