{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:58Z","timestamp":1747149298710,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of ramosetron after gynecological laparoscopic surgery on the recovery of bowel function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective randomized controlled trial conducted at Kyung Hee University hospital, South Korea, from August 2016 to September 2017. Patients were randomized to receive either 10\u00a0mg dexamethasone before induction of anesthesia (control group C), followed by intravenous administration of patient\u2010controlled analgesia (IV\u2010PCA) or 2\u00a0ml normal saline before induction of anesthesia and 0.6\u00a0mg ramosetron (study group R) administered with IV\u2010PCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 88 patients were enrolled. Times to first flatus (group C 23.98\u00a0\u00b1\u00a06.31 vs. group R 27.14\u00a0\u00b1\u00a09.56\u00a0h; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.148) and first defecation (group C 36.16\u00a0\u00b1\u00a016.04 vs. group R 43.41\u00a0\u00b1\u00a020.01\u00a0h; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.138) showed no statistically significant differences. No significant differences were observed in the frequency of postoperative nausea and vomiting (PONV) and demand for additional analgesics. Multiple linear regression for analysis of factors affecting time to first flatus revealed no significant results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ramosetron did not delay bowel movement recovery after gynecologic laparoscopic surgery and was as effective as dexamethasone in regulating PONV. Ramosetron can be used with IV\u2010PCA without concerns about delay in recovery of bowel function.<\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> registration number: NCT02849483.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13969","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T16:41:27Z","timestamp":1633711287000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A randomized controlled trial of the effect of ramosetron on postoperative restoration of bowel motility after gynecologic laparoscopic surgery"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-1375","authenticated-orcid":false,"given":"Hee Yong","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngsoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Hee","family":"You","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199909000-00022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018236"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519871171"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.200244"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0070620"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1473-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000174"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318293ee55"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.120238"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1455"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2016.10.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2019.03.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05299.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-006-0436-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0344-2"},{"issue":"10","key":"e_1_2_7_19_1","first-page":"CD012859","article-title":"Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta\u2010analysis","volume":"10","author":"Weibel S","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2010.02.002"}],"container-title":["International Journal of Gynecology &amp; 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