{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:06:14Z","timestamp":1782882374704,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the efficacy of CO<jats:sub>2<\/jats:sub>\u00a0laser treatment in postmenopausal women with vulvovaginal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>PubMed, Embase, Cochrane Library and Web of Science were searched to June 9, 2020. Prospective studies on the efficacy of CO<jats:sub>2<\/jats:sub>\u00a0laser treatment were included. Two researchers independently reviewed articles and extracted data. Heterogeneity test was conducted for each outcome indicator. Sensitivity analysis was performed in all models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve articles including 459 participants were enrolled. Compared with baseline, vaginal health indeices (VHIs) were significantly higher at the 1\u2010, 3\u2010, 6\u2010, and 12\u2010month follow ups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). For VVA severity, the visual analog scale scores for vaginal dryness at 1\u2010, 3\u2010, 6\u2010, and 12\u2010month follow\u2010ups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.050), vaginal burning, itching, and dysuria at 1\u2010month follow up (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and dyspareunia at 1\u2010, 3\u2010, 6\u2010, and 12\u2010month follow\u2010ups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were all significantly lower. For FSFI, total scores at 1\u2010, 3\u2010, 6\u2010, and 12\u2010month follow ups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and the scores in desire, arousal, lubrication, orgasm, satisfaction, and pain at 1\u2010month follow up (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.050) were all significantly higher. For quality of life, the PCS12 and MCS12\u00a0scores were all significantly higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.050) at the 1\u2010month follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CO<jats:sub>2<\/jats:sub>\u00a0laser treatment may be effective for postmenopausal women with VVA symptoms in improving quality of life and sexual function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13973","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T10:50:08Z","timestamp":1633776608000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of CO<sub>2<\/sub> laser treatment in postmenopausal women with vulvovaginal atrophy: A meta\u2010analysis"],"prefix":"10.1002","volume":"158","author":[{"given":"Meichen","family":"Liu","sequence":"first","affiliation":[{"name":"Tenth Department Plastic Surgery Hospital 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