{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:31:49Z","timestamp":1785198709876,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005961","name":"Universidad Nacional de Cuyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether circulating heat shock proteins HSP27\/HSPB1 and HSP90\u03b1\/HSPC1\u00a0may be useful for early prediction of the occurrence of pre\u2010eclampsia in asymptomatic women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have measured by ELISA the levels of HSPB1, HSPC1, and placental protein 13 (PP13) in serum samples from 44 women in the first trimester (10\u201312\u00a0weeks) and second trimester (17\u201320\u00a0weeks) of pregnancy. Western blot and immunohistochemistry for HSPB1 and HSPC1 were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HSPB1\u00a0serum levels were higher in women with pre\u2010eclampsia than in normotensive pregnant women at the first and second trimester (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), whereas PP13\u00a0levels decreased in women with pre\u2010eclampsia only in the first trimester of gestation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). We also observed higher HSPB1\u00a0levels in patients with early\u2010onset pre\u2010eclampsia in the first and second trimester (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study points out that circulating HSPB1\u00a0levels in first and second trimester might be useful for predicting the occurrence of pre\u2010eclampsia in asymptomatic women. Further validation studies are needed to finally establish this protein as a candidate predictive biomarker of pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13982","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T18:54:34Z","timestamp":1634496874000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Circulating heat shock protein 27 (HSPB1) levels in prediction of pre\u2010eclampsia: A pilot study"],"prefix":"10.1002","volume":"158","author":[{"given":"Raquel L.","family":"Martin","sequence":"first","affiliation":[{"name":"Lagomaggiore Hospital Mendoza Argentina"},{"name":"Medical School National University of Cuyo Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra L.","family":"Sottile","sequence":"additional","affiliation":[{"name":"Tumor Biology Laboratory Institute of Medicine and Experimental Biology of Cuyo National Research Council of Argentina\u2010National University of Cuyo Mendoza Argentina"},{"name":"Medical School University of Mendoza Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analia L.","family":"Redondo","sequence":"additional","affiliation":[{"name":"Medical School National University of Cuyo Mendoza Argentina"},{"name":"Tumor Biology Laboratory Institute of Medicine and Experimental Biology of Cuyo National Research Council of Argentina\u2010National University of Cuyo Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Tumor Biology Laboratory Institute of Medicine and Experimental Biology of Cuyo National Research Council of Argentina\u2010National University of Cuyo Mendoza Argentina"},{"name":"Medical School University of Mendoza Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisel 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