{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:09:31Z","timestamp":1789596571467,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare between 200 and 800\u00a0\u03bcg of vaginal misoprostol for cervical ripening before operative hysteroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quadruple\u2010blind randomized clinical trial conducted between November 2019 and September 2020 involving 76 patients undergoing cervical dilatation before surgical hysteroscopy at teaching hospitals in Pernambuco, Brazil. Women received the vaginal misoprostol dosage of 200 or 800\u00a0\u03bcg,10\u201312\u00a0h before operative hysteroscopy. The cervical width was the primary outcome, and secondary outcomes were patient satisfaction, adverse effects, surgical complications, and duration of cervical dilatation. Chi\u2010square tests of association, Fisher's exact and Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests were used with an \u03b1 error of &lt;5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistical difference between the groups in the mean of the cervical width (800\u00a0\u03bcg: 6.5\u00a0\u00b1\u00a01.6\u00a0mm vs 200\u00a0\u03bcg: 5.8\u00a0\u00b1\u00a01.8\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.055), patient satisfaction, and surgical findings, but the duration of cervical dilatation was lower in the 800\u2010\u03bcg group (28.16\u00a0\u00b1\u00a028.5\u00a0s vs 41.97\u00a0\u00b1\u00a031.0\u00a0s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035). Among the adverse effects, diarrhea was more frequent in the 800\u2010\u03bcg group with statistical difference (100% vs 0%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For cervical ripening, 200\u00a0\u03bcg misoprostol is equally effective with fewer adverse effects than 800\u00a0\u03bcg before operative hysteroscopy. ClinicalTrials.gov: NCT04152317. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04152317\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04152317<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13984","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T16:02:02Z","timestamp":1635177722000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison between 200\u00a0\u03bcg and 800\u00a0\u03bcg of vaginal misoprostol for cervical ripening before operative hysteroscopy: A randomized controlled trial"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-7922","authenticated-orcid":false,"given":"Maria da Concei\u00e7\u00e3o Farias Souto","family":"Maior","sequence":"first","affiliation":[{"name":"Postgraduate Program in Integral Health Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)  Recife Pernambuco Brazil"},{"name":"Biological Sciences and Health Center Catholic University Pernambuco (UNICAP)  Recife Pernambuco Brazil"},{"name":"Department of Health Science University Center Maur\u00edcio de Nassau (UNINASSAU)  Recife Pernambuco Brazil"},{"name":"Department of Gynecology Hospital Agamenon Magalh\u00e3es (HAM)  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-2052","authenticated-orcid":false,"given":"Alex Sandro Rolland","family":"Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Integral Health Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)  Recife Pernambuco Brazil"},{"name":"Biological Sciences and Health Center Catholic University Pernambuco (UNICAP)  Recife Pernambuco Brazil"},{"name":"Department of Maternal and Child Healthcare Federal University of Pernambuco (UFPE)  Recife Pernambuco 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