{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:04:14Z","timestamp":1767675854398},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate whether serum HE4 was associated with clinical risk prognostic factors and survival outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 72 patients with primary peritoneal carcinoma (PPC) from January 2011 to October 2019 participated. Serum HE4 and CA125 levels were detected at primary diagnosis, post\u2010surgery, pre\u2010recurrence and the presence of recurrence. The relations between serum HE4 levels with clinical prognostic factors were analyzed, and the hazard ratios between serum HE4 levels with overall survival and recurrence\u2010free survival were also analyzed by univariate and multivariate survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HE4 and CA125 levels were significantly elevated in serous type, high histological grade, advanced stage and positive lymph node status and residual tumor diameter more than 1\u00a0cm, respectively, compared with those in non\u2010serous type, low histological grade, early stage, negative lymph node status and residual tumor diameter no more than 1\u00a0cm, respectively. HE4 was an independent prognostic factor for recurrence\u2010free survival and overall survival with hazard ratios of 5.36 (95% confidence interval: 2.19\u201313.15) and 4.48 (95% confidence interval: 1.87\u201310.74), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HE4 is correlated with clinical risk prognostic factors in PPC and is effective in the recurrence detection and predicting outcome in PPC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14006","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T17:14:20Z","timestamp":1636046060000},"page":"352-358","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum HE4 is associated with clinical prognostic factors and survival outcome in female patients with primary peritoneal carcinoma"],"prefix":"10.1002","volume":"158","author":[{"given":"Dong","family":"Mi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Tianjin Central Hospital of Obstetrics and Gynecology Affiliated Maternity Hospital of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Tianjin Central Hospital of Obstetrics and Gynecology Affiliated Maternity Hospital of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Tianjin Central Hospital of Obstetrics and Gynecology Affiliated Maternity Hospital of Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(59)90287-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90081-F"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.073"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00650-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.05.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.04.041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1028-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1724600818796595"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163949"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150130"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182070f17"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182225509"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1943-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1457436"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.10.036"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2115-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-017-1026-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1360138"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4324-z"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.237"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00214-7"}],"container-title":["International Journal of Gynecology &amp; 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