{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:03:59Z","timestamp":1791947039257,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pregnant patients are potentially vulnerable to COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To clarify the clinical features of COVID\u201019 and analyze maternal\/fetal morbidity and mortality and the obstetric and neonatal outcomes of pregnant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Embase, PubMed, Web of Science, CINAHAL, LILACS, Google Scholar, and Scopus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Articles published from December 2019 to February 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>The reviewers extracted relevant data from the full\u2010text. Data synthesis was performed using the R\u20104.1.0 Project for Statistical Computing for Windows. The meta\u2010analysis of the included studies was carried out using the random\u2010effects model (DerSimonian and Laird). Heterogeneity was measured using <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 70\u00a0studies included 10\u00a0047 pregnant women with COVID\u201019, of whom 71.6% were in their third trimester. The most common symptoms were fever, cough, chest pain, dyspnea, and fatigue. Most newborns were delivered preterm (24%, 95% confidence interval [CI] 0.17\u20130.34, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a093%) and via cesarean delivery (42%, 95% CI 0.38\u20130.47, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a092%). There were 108\u00a0maternal mortalities (2%, 95% CI 0.01\u20130.03, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a054%) and 50 abortions (5%, 95% CI 0.03\u20130.09, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a073%). The neonatal outcomes included fetal distress (11%, 95% CI 0.06\u20130.19, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a091%), birth weight (15%, 95% CI 0.10\u20130.21, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a076%), APGAR &lt;7 (19%, 95% CI 0.12\u20130.28, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a043%), admission to the neonatal intensive care unit (28%, 95% CI 0.17\u20130.43, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a090%), and fetal mortality (2%, 95% CI 0.01\u20130.03, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a046%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\u00a0There was no evidence of severe acute respiratory syndrome coronavirus\u20102 in the placenta, breast milk, umbilical cord, and amniotic fluid of pregnant patients.<\/jats:p><jats:p>PROSPERO registration number: CRD42020181519.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14015","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T17:24:54Z","timestamp":1636651494000},"page":"394-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Consequences and implications of the coronavirus disease (COVID\u201019) on pregnancy and newborns: A comprehensive systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"156","author":[{"given":"Kleyton S.","family":"de Medeiros","sequence":"first","affiliation":[{"name":"Health Sciences Postgraduate Program Federal University of Rio Grande do Norte (UFRN)  Natal Rio Grande do Norte Brazil"},{"name":"Department of Nursing Centro Universit\u00e1rio do Rio Grande do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayane C. 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