{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:57:04Z","timestamp":1756310224209,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between NADPH oxidase p22phox subunit (<jats:italic>CYBA<\/jats:italic>; C242T) and superoxide dismutase 2 (<jats:italic>SOD2<\/jats:italic>; A16V) polymorphisms and the risk of preeclampsia (PE) in Chinese women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study included 325 patients with PE and 1294 controls. The genotypes were determined by polymerase chain reaction\u2010restriction\u00a0fragments\u00a0length\u00a0polymorphism method. Clinical, metabolic, and oxidative stress parameters were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with T allele of the <jats:italic>CYBA<\/jats:italic> C242T polymorphism had a decreased risk of PE (OR\u00a0=\u00a00.62, 95% CI: 0.42\u20130.92, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016) and those with the A allele of the <jats:italic>SOD2<\/jats:italic> A16V polymorphism had increased risk of PE (OR\u00a0=\u00a01.44, 95% CI: 1.09\u20131.89, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010). The coexistence of the <jats:italic>SOD2<\/jats:italic> AA\u00a0+\u00a0AV genotypes and the <jats:italic>CYBA<\/jats:italic> CC genotype further increased the risk of PE (OR\u00a0=\u00a02.32, 95% CI: 1.31\u20134.10, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) when the CT\u00a0+\u00a0TT\/VV combined genotype was the reference category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The T allele of the <jats:italic>CYBA<\/jats:italic> C242T polymorphism is related to a decreased risk of PE, while the A allele of the <jats:italic>SOD2<\/jats:italic> A16V polymorphism and its combination with the <jats:italic>CYBA<\/jats:italic> CC genotype are associated with an increased risk of PE in Chinese women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14044","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T09:58:33Z","timestamp":1637920713000},"page":"597-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of <i>CYBA<\/i> C242T and superoxide dismutase 2 A16V genetic variants with preeclampsia"],"prefix":"10.1002","volume":"158","author":[{"given":"Kaifeng","family":"Hu","sequence":"first","affiliation":[{"name":"Laboratory of Genetic Disease and Perinatal Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of Education West China Second University Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan 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