{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:41:00Z","timestamp":1789202460114,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 29\u00a0618 women underwent combined screening and 301\u00a0566 women received standard care. Women who had combined screening were less likely to have preeclampsia, preterm birth, small neonates, and low Apgar scores than the general population. Women with high\u2010risk results (\u22651 in 100) were more likely to develop preterm preeclampsia (2.1% vs. 0.7%, risk ratio [RR] 3.04, 95% CI 2.46\u20133.77), while low\u2010risk women (risk &lt;1 in 100) had lower rates of preterm preeclampsia (0.2% vs. 0.7%, RR 0.26, 95% CI 0.19\u20130.35) and other pregnancy complications. Screening detected 65.2% (95% CI 56.4\u201373.2%) of all preterm preeclampsia cases, with improved performance after adjustment for treatment effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First trimester screening for preeclampsia in clinical practice identified a population at high risk of adverse pregnancy outcomes and low\u2010risk women who may be suitable for less intensive antenatal care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14049","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T09:50:42Z","timestamp":1638006642000},"page":"634-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Routine first trimester combined screening for preterm preeclampsia in Australia: A multicenter clinical implementation cohort study"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"Daniel L.","family":"Rolnik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Ritchie Centre Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-5594","authenticated-orcid":false,"given":"Roshan J.","family":"Selvaratnam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Ritchie Centre Monash University  Clayton Victoria Australia"},{"name":"Department of Health and Human Services Safer Care Victoria Victorian Government  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-5778","authenticated-orcid":false,"given":"Dagmar","family":"Wertaschnigg","sequence":"additional","affiliation":[{"name":"Ambulatorium f\u00fcr Fetalmedizin  Feldkirch Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Meagher","sequence":"additional","affiliation":[{"name":"Monash Ultrasound for Women  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-5233","authenticated-orcid":false,"given":"Euan","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8019-1289","authenticated-orcid":false,"given":"Jon","family":"Hyett","sequence":"additional","affiliation":[{"name":"Discipline of Obstetrics, Gynaecology and Neonatology Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Maternal Fetal Medicine Unit Royal Prince Alfred Hospital  Sydney New South Wales 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