{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:51:11Z","timestamp":1773960671203,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Atypical polypoid adenomyoma (APA) is a rare uterine premalignant lesion mainly occurring in premenopausal and nulliparous women. Although hysteroscopic resection (HR) has showed promising results, the conservative management of APA in young women is not standardized, and few data are available in the literature. We aimed to assess oncologic outcomes of the conservative treatment of APA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter observational retrospective cohort study was performed including all patients with APA who underwent conservative treatment from January 2006 to June 2020. Rates of each oncologic outcome (i.e. initial complete response, persistence, progression to cancer, recurrence, long\u2010term treatment success, and treatment failure) were calculated for all conservative treatment together and separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients were included. Conservative treatments consisted of HR alone (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) and HR\u00a0+\u00a0progestin (<jats:italic>n<\/jats:italic>\u00a0=\u00a011). Overall, 24 (96%) patients showed initial complete response, of which 21 (84%) showed long\u2010term treatment success; four (16%) patients had progression to cancer, of which two (8%) first recurred as APA. Long\u2010term treatment success was achieved in 13 of 14 (92.9%) patients with HR alone and 8 of 11 (72.3%) with HR\u00a0+\u00a0progestin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Conservative treatment appears to be a safe option in women with APA. The four\u2010steps HR might be considered as the first\u2010line conservative approach, while the addition of progestin does not seem to improve oncologic outcomes. However, the risk of progression to cancer highlights the need for a close and long\u2010term follow up with ultrasonography and hysteroscopic biopsies, and for hysterectomy in patients not desiring pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14077","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T15:14:05Z","timestamp":1639840445000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oncologic outcomes of conservative treatment of atypical polypoid adenomyoma of the uterus: A two\u2010center experience"],"prefix":"10.1002","volume":"159","author":[{"given":"Paolo","family":"Casadio","sequence":"first","affiliation":[{"name":"Division of Gynecology and Human Reproduction Physiopathology Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero\u2010Univeristaria di Bologna, S. Orsola Hospital University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-2333","authenticated-orcid":false,"given":"Antonio","family":"Raffone","sequence":"additional","affiliation":[{"name":"Division of Gynecology and Human Reproduction Physiopathology Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero\u2010Univeristaria di Bologna, S. Orsola Hospital University of Bologna  Bologna Italy"},{"name":"Gynecology and Obstetrics Unit Department of Neuroscience, Reproductive Sciences and Dentistry School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit Department of Advanced Biomedical Sciences School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Division of Gynecology and Human Reproduction Physiopathology Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero\u2010Univeristaria di Bologna, S. 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