{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:59:38Z","timestamp":1774936778824,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1033514"],"award-info":[{"award-number":["OPP1033514"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011072","name":"Center for AIDS Research, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["P30 AI50410"],"award-info":[{"award-number":["P30 AI50410"]}],"id":[{"id":"10.13039\/100011072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["NGP10161"],"award-info":[{"award-number":["NGP10161"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of HIV co\u2010infection on non\u2010treponemal titers during pregnancy in women with syphilis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a secondary analysis of pregnant women with syphilis in the prospective, observational Zambian Preterm Birth Prevention Study (ZAPPS). Treponemal (<jats:italic>Treponema pallidum<\/jats:italic> particle agglutination) and non\u2010treponemal (rapid plasma reagin; RPR) testing were performed on serum biospecimens, resulting in 47 participants with serologically confirmed syphilis (27 HIV\u2010positive, 20 HIV\u2010negative). The primary outcome, achievement of RPR titer seroreduction during pregnancy, was analyzed by logistic regression. Secondary outcomes included overall titer reduction, seroreduction rate, serologic cure, and adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seroreduction of RPR titer occurred in 78% (21\/27) of women with HIV versus 45% (9\/20) of women without (adjusted odds ratio 4.66; 95% confidence interval [CI] 1.14\u00a0\u2212\u00a019.08). Overall RPR titer reduction, rate of seroreduction per week, and the proportion achieving serologic cure each trended higher among women with HIV compared with those without HIV. There was a trend toward decreased stillbirth incidence in participants achieving seroreduction (odds ratio 0.15, 95% CI 0.01\u20131.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HIV co\u2010infection in this cohort of Zambian women with syphilis was associated with greater odds of RPR titer seroreduction during pregnancy. Pregnant women with syphilis and HIV may not be at increased risk for a delayed syphilis treatment response compared with women without HIV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14131","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T14:39:27Z","timestamp":1644071967000},"page":"427-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Seroreduction of syphilis non\u2010treponemal titers during pregnancy for women with and without <scp>HIV<\/scp> co\u2010infection"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-823X","authenticated-orcid":false,"given":"Carolyn M.","family":"Webster","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Obstetrics and Gynecology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret P.","family":"Kasaro","sequence":"additional","affiliation":[{"name":"UNC Global Projects Zambia  Lusaka Zambia"},{"name":"Department of Obstetrics and Gynecology University of Zambia School of Medicine  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-0405","authenticated-orcid":false,"given":"Joan T.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"UNC Global Projects Zambia  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Stringer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Wiesen","sequence":"additional","affiliation":[{"name":"The Odum Institute University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bellington","family":"Vwalika","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Obstetrics and Gynecology University of Zambia School of Medicine  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S. A.","family":"Stringer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211720"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.047514"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.021402"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/589295"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1209-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11785"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"140","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/FM9.0000000000000018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.12688\/gatesopenres.12820.1"},{"key":"e_1_2_9_11_1","unstructured":"World Health Organization.Global health sector strategy on sexually transmitted infections 2016\u20132021: Towards ending STIs.WHO\/RHR\/16.09.2016:64."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.12688\/gatesopenres.13046.1"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:43:26Z","timestamp":1692697406000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/ijgo.14131"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14131","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"assertion":[{"value":"2021-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}