{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:24:35Z","timestamp":1790727875450,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although Tao brush has become one of the most studied and used endometrial cytological samplers, concerns remain about the adequacy of the cytological sample compared with definitive histology. We aimed to assess accuracy of cytological examination from Tao brush sampling in diagnosing endometrial premalignancy and malignancy through a systematic review and meta\u2010analysis. Seven electronic databases were searched from January 2000 to July 2021 for all studies which allowed assessment of accuracy of Tao brush in diagnosing endometrial premalignancy and malignancy. We calculated sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR\u2212), diagnostic odds ratio (DOR) and area under the curve (AUC) on summary receiver operating characteristic (SROC) curve. Five studies with 774 patients were included. In diagnosing endometrial premalignancy and malignancy, cytological examination from Tao brush endometrial sampling showed pooled sensitivity of 0.95 (95% CI, 0.90\u20130.98), specificity of 0.92 (95% CI, 0.90\u20130.94), LR+ of 12.73 (95% CI, 3.94\u201341.18), LR\u2212 of 0.09 (95% CI, 0.05\u20130.18), DOR of 184.84 (95% CI, 24.37\u20131401.79), AUC of 0.9757 (standard error: 0.013). In conclusion, cytological examination from Tao brush seems to have a high diagnostic accuracy and might be proposed as both screening and diagnostic tool. However, further studies are necessary to confirm these findings.<\/jats:p>","DOI":"10.1002\/ijgo.14204","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T06:40:12Z","timestamp":1648881612000},"page":"615-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Accuracy of cytological examination of Tao brush endometrial sampling in diagnosing endometrial premalignancy and malignancy"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-2333","authenticated-orcid":false,"given":"Antonio","family":"Raffone","sequence":"first","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC) IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna. S. Orsola Hospital. University of Bologna  Bologna Italy"},{"name":"Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC) IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna. S. Orsola Hospital. University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Raspollini","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC) IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna. S. Orsola Hospital. University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Oliviero","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry \"Schola Medica Salernitana\" University of Salerno  Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Gynecopathology and Breast Pathology Unit, Department of Woman's Health Science Agostino Gemelli University Polyclinic  Rome Italy"},{"name":"Anatomic Pathology Unit, Department of Advanced Biomedical Sciences, School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Santoro","sequence":"additional","affiliation":[{"name":"Gynecopathology and Breast Pathology Unit, Department of Woman's Health Science Agostino Gemelli University Polyclinic  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Renzulli","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC) IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna. S. Orsola Hospital. University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lopez","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry \"Schola Medica Salernitana\" University of Salerno  Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Michele Di","family":"Maio","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry \"Schola Medica Salernitana\" University of Salerno  Baronissi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Casadio","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC) IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna. S. Orsola Hospital. 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