{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:14:16Z","timestamp":1769915656723,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the neonatal survival rate after intra\u2010fetal laser (IFL) treatment for twin reversed arterial perfusion (TRAP) sequence, and to investigate the effect of gestational age at the time of procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of TRAP sequences followed at our institution from 2013\u20132020. Systematic review and meta\u2010analysis of the neonatal survival rate after IFL was conducted. Both diamniotic and monoamniotic monochorionic pregnancies were included. A subgroup analysis to compare outcomes according to gestational age at procedure (&lt;16<jats:sup>+0<\/jats:sup> weeks or \u226516<jats:sup>+0<\/jats:sup> weeks) was planned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen pregnancies were followed at our center and seven were treated with IFL: the survival rate was 57%. Ten studies published between 2008 and 2020 for a total of 156 cases were included in the meta\u2010analysis. The overall neonatal survival after IFL was 79% (95% CI 0.72\u20130.86, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 22%). A random\u2010effects model comparing neonatal survival for IFL performed &lt;16<jats:sup>+0<\/jats:sup> weeks versus \u226516<jats:sup>+0<\/jats:sup> weeks showed no significant difference between the two groups (OR\u00a0=\u00a00.93; 95% CI 0.37\u20132.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IFL is a safe and minimally invasive technique for the treatment of TRAP sequence, with a survival rate of 79%. Gestational age at treatment (before or after 16\u2009weeks) does not seem to affect neonatal survival rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14221","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T09:05:33Z","timestamp":1650272733000},"page":"833-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Timing of intra\u2010fetal laser therapy for twin reversed arterial perfusion (<scp>TRAP<\/scp>) sequence: Retrospective series and systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"159","author":[{"given":"Annachiara","family":"Vitucci","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology ASST Spedali Civili and Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fratelli","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology ASST Spedali Civili and Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-0823","authenticated-orcid":false,"given":"Anna","family":"Fichera","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology ASST Spedali Civili and Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Sartori","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology ASST Spedali Civili and Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-714X","authenticated-orcid":false,"given":"Federico","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology ASST Spedali Civili and Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S214254"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00250.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.16013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20860"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13229"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_8_1","unstructured":"WellsG SheaB O'ConnellD PetersonJ WelchV LososM et al.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_10_9_1","volume-title":"Systematic Reviews: CRD's Guidance for Undertaking Reviews in Health Care","author":"Centre for Reviews and Dissemination","year":"2009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"WallaceBC DahabrehIJ TrikalinosTA LauJ TrowP SchmidCH:20122012;49:15 Closing the gap between methodologists and end\u2010users:Ras a computational Back\u2010end.","DOI":"10.18637\/jss.v049.i05"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2025"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334156"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12578"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12495"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358593"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503389"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5707"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.10.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.046"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343223"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8924"},{"issue":"459","key":"e_1_2_10_22_1","first-page":"e451","article-title":"Efficacy of radiofrequency ablation for twin\u2010reversed arterial perfusion sequence","volume":"196","author":"Lee H","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4353"},{"issue":"213","key":"e_1_2_10_24_1","first-page":"e211","article-title":"The outcome of twin reversed arterial perfusion sequence diagnosed in the first trimester","volume":"203","author":"Lewi L","year":"2010","journal-title":"Am J Obstet Gynecol"}],"container-title":["International Journal of Gynecology &amp; 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