{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:53:01Z","timestamp":1784123581562,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify the fetal safety of herbal Kampo medicines, including Hange\u2010koboku\u2010to, Koso\u2010san, Nyoshin\u2010san, Yokukansan, Yokukansan\u2010kachinpi\u2010hange, Saiko\u2010keishikankyo\u2010to, Keishi\u2010karyukotu\u2010borei\u2010to, and Kanbaku\u2010taisou\u2010to, when administered to pregnant women with depression using a large healthcare administrative database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted data from the JMDC Claims Database (2005\u20132018) for this retrospective cohort study of pregnant women aged 19\u2009years or older admitted to obstetric clinics or hospitals for delivery. Participants were classified into four groups: those without depression, those diagnosed with depression without medication, those given Kampo medicines for depression, and those given western medicines for depression. Neonatal outcomes (congenital anomalies, low birth weight, and preterm birth) were considered as the safety outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 179\u2009707 eligible mothers. The adverse outcomes did not differ significantly between participants receiving Kampo medicine and those not diagnosed with depression during pregnancy. The proportion of low\u2010birth\u2010weight neonates did not differ significantly between the Kampo medicine and non\u2010depression groups (adjusted odds ratio [aOR] 1.28; 95% confidence interval [CI] 0.86\u20131.91), but was significantly higher in the unmedicated depression group (aOR 1.31; 95% CI 1.07\u20131.61) and western medicine group (aOR 1.47; 95% CI 1.18\u20131.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Kampo medicines are safe for treating depression during pregnancy without increasing the incidence of congenital anomalies, low birth weight, or preterm birth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14237","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T13:22:52Z","timestamp":1651411372000},"page":"865-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Safety of Japanese herbal Kampo medicines for the treatment of depression during pregnancy"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-114X","authenticated-orcid":false,"given":"Nobuaki","family":"Michihata","sequence":"first","affiliation":[{"name":"Department of Health Services Research, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Shigemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Yamana","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000116689.75396.5f"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1547"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-2101-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1607649"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.11.033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30309"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.684"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.111"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013372"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.5012-20"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.762895"},{"key":"e_1_2_9_13_1","first-page":"89","article-title":"Pregnancy and Kampo","volume":"52","author":"Yaegashi M","year":"2000","journal-title":"Nippon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12781"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0637-9760"},{"key":"e_1_2_9_16_1","first-page":"244","article-title":"Efficacy of kampo medicine for maternal mental health","volume":"21","author":"Shiota A","year":"2017","journal-title":"J Jpn Soc Psychosom Obstet Gynecol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.je20090066"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03019.x"},{"key":"e_1_2_9_20_1","unstructured":"RoundingC RandallK Forrester\u2010BarkerJ KurinczukJJ.Fourth report of the congenital anomaly register for Oxfordshire Berkshire and Buckinghamshire (CAROBB) births 2005\u20132012. 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University of Oxford;2014."},{"key":"e_1_2_9_21_1","first-page":"274","article-title":"Two cases of psychiatric disorders in pregnant women effectively treated with herbal Kampo medicine","volume":"51","author":"Okamura M","year":"2014","journal-title":"Kanto J Obst Gynec"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145920"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:50:43Z","timestamp":1692438643000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/ijgo.14237"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14237","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"2021-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}