{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:24Z","timestamp":1786977804405,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012411","name":"Alborz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate possible interactions of magnesium sulfate\u2014the drug of choice in the management of pre\u2010eclampsia\/eclampsia\u2014in response to a few case reports that revealed maternal electrolyte disturbances, especially symptomatic changes, following magnesium sulfate administration in pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively, women with pre\u2010eclampsia were given 4\u00a0g of intravenous magnesium sulfate followed by a 2\u00a0g\/h infusion up to 24\u2009h after delivery. Sequential blood samples were drawn from each patient and used to measure the serum levels of sodium, potassium, calcium, phosphorus, magnesium, and parathyroid hormone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 30 pregnant women with pre\u2010eclampsia were evaluated. They were aged between 20 and 41\u2009years with median gestational age of 37.6 (interquartile range 35.4\u201338.9) weeks. Only five patients reached the therapeutic window of magnesium in at least one of our measuring intervals during magnesium sulfate infusion. Plasma magnesium concentrations increased significantly during magnesium sulfate administration and dropped during the next 12 and 24\u2009h after infusion discontinuation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.05). Fifteen of 30 (50%) patients developed asymptomatic hypocalcemia, mainly at hour 24 of infusion. Negative moderate correlations were detected between the calcium and magnesium concentrations at 12 and 24\u2009hours of infusion (\u03c1\u00a0=\u00a0\u22120.390,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.044 and \u03c1\u00a0=\u00a00.315,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.096, respectively). None of the patients with hypocalcemia reached the therapeutic level of magnesium or experienced parallel hyperphosphatemia. Eleven of 30 (36.6%) patients developed hyperphosphatemia mainly at 2 and 12\u2009h of magnesium sulfate infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study implies that magnesium sulfate could cause hypermagnesemia\u2010induced hypocalcemia in women with pre\u2010eclampsia, independent from parathyroid hormone. The negative correlations between calcium and magnesium concentrations could be indicative of dose\u2010dependent associations between serum magnesium level and degree of hypocalcemia in our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.14296","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T03:53:56Z","timestamp":1654228436000},"page":"938-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of magnesium sulfate on maternal serum electrolytes and parathyroid hormone in pre\u2010eclampsia"],"prefix":"10.1002","volume":"159","author":[{"given":"Masoumeh","family":"Farahani","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-1001","authenticated-orcid":false,"given":"Niusha","family":"Sharifinejad","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hashemnejad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banafsheh","family":"Mashak","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Mahboubipour","sequence":"additional","affiliation":[{"name":"Gastroenterology Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Farahani","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadith","family":"Rastad","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matineh","family":"Nirouei","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853127"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8401"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407866-6.00012-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-195"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2381"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-34"},{"issue":"31","key":"e_1_2_10_9_1","first-page":"1453","article-title":"Hypocalcemic delirium due to magnesium sulphate therapy in a pregnant woman with pre\u2010eclampsia","volume":"146","author":"Ganzevoort JW","year":"2002","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.356"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2010.484082"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03190370059013"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"430","article-title":"Urinary magnesium, calcium, and phosphate excretion during magnesium sulfate infusion","volume":"58","author":"Cruikshank DP","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405103101904"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.7.1764"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-986696"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2011.110084"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12380"},{"key":"e_1_2_10_19_1","unstructured":"SayyedA SonttakeA StudentP.Electrolyte status in preeclampsia.2018."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_10_21_1","volume-title":"Hypertensive Disorders. 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