{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:43:09Z","timestamp":1787784189086,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess complication rates of patients undergoing a second\u2010trimester medical termination for intrauterine fetal demise compared with fetal anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study comparing patients undergoing medical termination for a fetal anomaly versus medical termination for intrauterine fetal demise (IUFD) before 24\u2009weeks of gestation. Data were collected from two urban academic medical centers from 2009 to 2019. Institutional review board approval was obtained from both institutions and patient consent was not required. We included singleton gestations between 14.0\u2009weeks and 23.6\u2009weeks undergoing induction with mifepristone and misoprostol or misoprostol alone. Groups were matched based on gestational age with a 1:1 ratio. The primary outcome was composite complication rate (retained placenta requiring dilation and curettage, suspected infection, hemorrhage, failed induction requiring dilation and evacuation, intensive care unit admission, and readmission).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010five patients were in each group. The groups differed in patient mean age (fetal anomaly 34\u2009years versus 31\u2009years for IUFD, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and mifepristone pretreatment (fetal anomaly 55% versus IUFD 5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Composite complication rate was similar (fetal anomaly 14% versus IUFD 17%), and specific complications did not differ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Second\u2010trimester medical termination for IUFDs have similar complication rates as those undergoing induction terminations for fetal anomalies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14302","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T09:18:51Z","timestamp":1655111931000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Complications of second\u2010trimester medical termination of pregnancy for fetal anomalies compared with intrauterine fetal demise"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-1904","authenticated-orcid":false,"given":"Erica","family":"Testani","sequence":"first","affiliation":[{"name":"From the Department of Obstetrics and Gynecology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Latta","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Gynecology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Barker","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Gynecology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sloane L.","family":"York","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Gynecology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Laursen","sequence":"additional","affiliation":[{"name":"From the Department of Obstetrics and Gynecology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","first-page":"1","article-title":"Abortion surveillance \u2010 United States, 2005","volume":"57","author":"Gamble SB","year":"2008","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.12.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.10.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318227214e"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000289577.32274.a5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2020.04.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701379853"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0144361031000120923"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.03.054"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013432"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.0938"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1998.tb00044.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123887"},{"key":"e_1_2_9_15_1","unstructured":"Gynuity health projects. Resources: map of mifepristone approval.2017.https:\/\/gynuity.org\/resources\/map\u2010of\u2010mifepristone\u2010approvals. 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