{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:58:27Z","timestamp":1790863107931,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012411","name":"Alborz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to examine the diagnostic value of ophthalmic artery Doppler indices in predicting preeclampsia along with other markers in the third trimester of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Normotensive pregnancies\u00a0were included during 28\u201332\u2009weeks of gestation to undergo uterine and ophthalmic artery Doppler ultrasound. Maternal and fetal characteristics were documented at the visit between the 28 and 32\u2009weeks of gestation, and pregnancy\u2010associated plasma protein A (PAPP\u2010A) values in the first trimester were collected to be integrated into a multiparametric prediction model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 795 included participants, 48 cases progressed to preeclampsia. All assessed ophthalmic Doppler parameters including first and second peak systolic velocities (PSVs), second to first peak ratio (PR), and pulsatility index (PI), were statistically different in patients who developed preeclampsia later on. The average PR (sensitivity: 100% [95% CI, 0.81\u20131.00]; specificity: 90% [95% CI, 0.86\u20130.93]) and PI between the eyes, PAPP\u2010A multiple of median and uterine artery PI were determined to be the most important predictors of PE, which were subsequently integrated into a multiple regression model (sensitivity: 94% [95% CI, 0.70\u20131.00]; specificity: 93% [95% CI, 0.89\u20130.96]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided a screening method for individuals at higher risk of progressing to preeclampsia in the third trimester of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14305","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:35:13Z","timestamp":1655134513000},"page":"120-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic value of ophthalmic artery Doppler indices for prediction of preeclampsia at 28\u201332\u2009weeks of gestation"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2149-632X","authenticated-orcid":false,"given":"Maasoumeh","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Naemi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-0138","authenticated-orcid":false,"given":"Sepehr","family":"Aghajanian","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboubeh","family":"Saleh","sequence":"additional","affiliation":[{"name":"Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-3553","authenticated-orcid":false,"given":"Kamran","family":"Hessami","sequence":"additional","affiliation":[{"name":"Maternal Fetal Care Center Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-7671","authenticated-orcid":false,"given":"Mahmood","family":"Bakhtiyari","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Iran"},{"name":"Department of Community Medicine, School of Medicine Alborz University of Medical Sciences  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"1131","article-title":"Hypertension in pregnancy: executive summary","volume":"122","year":"2013","journal-title":"Obstetr Gynecol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22823"},{"key":"e_1_2_9_6_1","first-page":"7","article-title":"Risk factors and effective management of preeclampsia","volume":"8","author":"English FA","year":"2015","journal-title":"Integr Blood Press Control"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2012.120007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23528"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(97)00264-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15241"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800094-6.00005-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5315"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038040-00002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23517"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22184"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.11.021"},{"issue":"4","key":"e_1_2_9_19_1","first-page":"559","article-title":"One\u2010stage screening for pregnancy complications by color doppler assessment of the uterine arteries at 23\u2009weeks' gestation11The authors thank Paul seed, division of primary care and health sciences, Guy's, King's and St. Thomas's hospitals, for valuable statistical input","volume":"96","author":"Albaiges G","year":"2000","journal-title":"Obstetr Gynecol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17403"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13313"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2020-000550"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.21949"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13338"},{"issue":"8812","key":"e_1_2_9_25_1","first-page":"182","article-title":"Ophthalmic artery velocimetry in pregnant women","volume":"340","author":"Hata T","year":"1992","journal-title":"Lancet (British Edition)"},{"key":"e_1_2_9_26_1","first-page":"723","article-title":"Maternal ophthalmic artery doppler velocimetry in pre\u2010eclampsia in southwestern Nigeria","volume":"7","author":"Olatunji RB","year":"2015","journal-title":"Int J Womens Health"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T10:44:24Z","timestamp":1692441864000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ijgo.14305"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14305","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"2022-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}