{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T19:03:05Z","timestamp":1785610985779,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate immediate oxytocin and early amniotomy compared with delayed amniotomy after Foley catheter cervical ripening in nulliparous women on intervention\u2010to\u2010delivery interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized trial was conducted from September 2020 to March 2021. A total of 140 term nulliparas (70 early amniotomy, 70 delayed amniotomy) with Foley catheter\u2013ripened cervices (dilatation \u22653\u00a0cm achieved), singleton fetus, cephalic presentation with intact membranes, and reassuring fetal heart rate tracing were recruited. Women were randomized to immediate titrated intravenous oxytocin infusion and early amniotomy or delayed amniotomy (after 4\u00a0h of oxytocin). The primary outcome was intervention (oxytocin)\u2010to\u2010delivery interval (h).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intervention\u2010to\u2010delivery intervals (h) were mean\u2009\u00b1\u2009standard deviation 9.0\u00a0\u00b1\u20093.6 versus 10.6\u00a0\u00b1\u20093.5\u00a0h (mean difference of 1.4\u00a0h) (<jats:italic>P<\/jats:italic>\u00a0=\u20090.004) for the early versus delayed amniotomy arms, respectively. Birth rates at 6\u00a0h after oxytocin infusion were 19 of 70 (27.1%) versus 8 of 70 (11.4%) (relative risk, 2.38 [95% confidence interval (CI), 1.11\u20135.06]; number needed to treat: 7 [95% CI, 3.5\u201334.4]) (<jats:italic>P<\/jats:italic>\u00a0=\u20090.03), cesarean delivery rates were 29 of 70 (41.4%) versus 33 of 70 (47.1%) (relative risk, 0.88; 95% CI, 0.61\u20131.28) (<jats:italic>P<\/jats:italic>\u00a0=\u20090.50), and maternal satisfaction on birth process were a median of 7 (interquartile range, 7\u20138) versus 7 (interquartile range, 7\u20138) (<jats:italic>P<\/jats:italic>\u00a0=\u20090.40) for the early versus delayed amniotomy arms, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In term nulliparas with cervices ripened by Foley catheter, immediate oxytocin and early amniotomy compared with a planned 4\u2010h delay to amniotomy shortened the intervention\u2010to\u2010delivery interval but did not significantly reduce the cesarean delivery rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14313","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T06:20:01Z","timestamp":1655792401000},"page":"951-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early versus delayed amniotomy with immediate oxytocin after Foley catheter cervical ripening in nulliparous labor induction: A randomized trial"],"prefix":"10.1002","volume":"159","author":[{"given":"Nur Adlyn","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Universiti Malaya, Jalan Profesor Diraja Ungku Aziz  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-2357","authenticated-orcid":false,"given":"Jesrine Gek Shan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and 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Chiong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Universiti Malaya, Jalan Profesor Diraja Ungku Aziz  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"NHS Maternity Statistics, England 2019\u20132020","author":"NHS Digital","year":"2020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03334-8"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000157436.68847.3b"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000152338.76759.38"},{"issue":"6","key":"e_1_2_13_6_1","first-page":"917","article-title":"Elective induction of labor as a risk factor for cesarean delivery among low\u2010risk women at term","volume":"95","author":"Maslow A","year":"2000","journal-title":"Obstet 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