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Preterm labor, miscarriage, gestational diabetes mellitus, and pre\u2010eclampsia are all caused by abnormal cytokine expression during pregnancy and childbirth. A disruption in the cytokine balance can lead to autoimmune diseases or microbiologic infections, or to autoimmune illness remission during pregnancy with postpartum recurrence. The cytokine treatments are essential and damaging to the developing fetus. The current review summarizes the known research on cytokine changes during pregnancy and their possible consequences for pregnant women. Studies suggest that customizing medication for each woman and her progesterone levels should be based on the cytokine profile of each pregnant woman. Immune cells and chemicals play an important function in development of the placenta and embryo. During pregnancy, T cells divide and move, and a careful balance between proinflammatory and anti\u2010inflammatory cytokines is necessary. The present review focuses on the mother's endurance in generating fetal cells and the immunologic mechanism involved.<\/jats:p>","DOI":"10.1002\/ijgo.14333","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T15:03:42Z","timestamp":1657465422000},"page":"516-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cytokine see\u2010saw across pregnancy, its related complexities and consequences"],"prefix":"10.1002","volume":"160","author":[{"given":"Arun","family":"Meyyazhagan","sequence":"first","affiliation":[{"name":"Center for Perinatal and Reproductive Medicine University of Perugia  Perugia Italy"},{"name":"PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haripriya","family":"Kuchi Bhotla","sequence":"additional","affiliation":[{"name":"Department of Life Sciences CHRIST (Deemed to be University)  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikantan","family":"Pappuswamy","sequence":"additional","affiliation":[{"name":"Department of Life Sciences CHRIST (Deemed to be University)  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Tsibizova","sequence":"additional","affiliation":[{"name":"PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine  Florence Italy"},{"name":"Institute of Perinatology and Pediatrics, Almazov National Medical Research Center  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Al Qasem","sequence":"additional","affiliation":[{"name":"PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine  Florence Italy"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Mutah University  Al\u2010Karak Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Carlo","family":"Di Renzo","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Reproductive Medicine University of Perugia  Perugia Italy"},{"name":"PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine  Florence Italy"},{"name":"Department of Obstetrics and Gynecology I.M. 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