{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:29:12Z","timestamp":1792592952345,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2019YFS0407"],"award-info":[{"award-number":["2019YFS0407"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the risk factors of recurrent high\u2010grade cervical intraepithelial neoplasia grade 2 or worse (CIN2+) after loop electrosurgical excision procedure (LEEP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included patients with histopathologically confirmed CIN2\/3 who underwent LEEP in 2015\u20132020. Cox regression analysis was used to evaluate the risk factors of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recurrent CIN2+ was found in 268 patients after LEEP (268\/4369, recurrence rate, 6.1%). High\u2010risk (hr\u2010) HPV infection (hazard ratio [HR] 12.09, 95% confidence interval [CI] 7.78\u201318.79), margin status (HR 6.48, 95% CI 4.75\u20138.84), baseline diagnosis (HR 1.45, 95% CI 1.08\u20131.95), smoking (HR 3.17, 95% CI 2.27\u20134.43), and immunosuppression (HR 1.96, 95% CI 1.33\u20132.91) were significant independent risk factors of recurrence. HPV16 (HR 3.61, 95% CI 2.43\u20135.37), HPV33 (HR 2.62, 95% CI 1.12\u20136.12), and HPV52 (HR 1.61, 95% CI 1.02\u20132.55) infection showed a higher risk of recurrence. High\u2010risk HPV had the highest accuracy (sensitivity 88.5%; negative predictive values 98.7%) in predicting recurrence compared with liquid\u2010based cytology test and margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given that positive margins present a higher risk, wide excision may be required to avoid residual lesions. More attention should be paid to the correlation between recurrence and hr\u2010HPV genotypes. After treatment for high\u2010grade CIN, HPV\u2010based testing is recommended at 6\u00a0months. Timely identification of high\u2010risk factors enables risk stratification, and enables individual management or individual follow\u2010up and recall strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14340","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T15:53:54Z","timestamp":1657468434000},"page":"538-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Risk factors analysis of recurrent disease after treatment with a loop electrosurgical excision procedure for high\u2010grade cervical intraepithelial neoplasia"],"prefix":"10.1002","volume":"160","author":[{"given":"Ting","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Information Management West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrong","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children West China Second Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(05)01761\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn099"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21604"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39363.471806.BE"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31202"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.08.042"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000130"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.15996"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.09.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30700\u20103"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33251"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0029\u20107844(01)01683\u20100"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0029\u20107844(00)01174\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(07)70283\u20108"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010010\u20101611\u20101"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000488"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000526"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.10.008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1401"}],"container-title":["International Journal of Gynecology &amp; 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