{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:12:48Z","timestamp":1747149168492,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["D161100002716004"],"award-info":[{"award-number":["D161100002716004"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To add to the limited data that exist on the selection of drugs to prevent mother\u2010to\u2010child transmission (MTCT) of hepatitis B virus (HBV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective cohort study that enrolled mothers with HBV\u2010DNA \u22652\u00a0\u00d7\u200910<jats:sup>5<\/jats:sup>\u00a0IU\/ml. All enrolled mothers received either tenofovir disoproxil fumarate (TDF) or telbivudine (LdT) to prevent HBV transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 270 mothers received TDF treatment and 275 mothers received LdT treatment. The predelivery decline in HBV\u2010DNA in the TDF group was higher than the LdT group (3.92\u2009\u00b1\u20090.93 log IU\/ml vs. 3.76\u2009\u00b1\u20090.94 log IU\/ml, <jats:italic>P<\/jats:italic>\u00a0=\u20090.043). In the primary analysis, the MTCT rate of the TDF group was comparable to that of the LdT group, both in the intention\u2010to\u2010treat analysis (1.5% [4\/275] vs. 1.8% [5\/273], <jats:italic>P<\/jats:italic>\u00a0&gt;\u20090.99) and the per\u2010protocol analysis (0% in both groups, <jats:italic>P<\/jats:italic>\u00a0&gt;\u20090.99). The alanine aminotransferase elevation rates in the TDF group were lower than in the LdT group (17.3% vs. 27.4%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.005). Less anorexia and more arthralgia were observed in the LdT group than the TDF group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TDF and LdT are both effective in preventing MTCT of HBV, but they may cause different adverse events. TDF is more effective in reducing HBV viral load and had fewer alanine aminotransferase abnormalities than LdT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14341","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T15:03:46Z","timestamp":1657551826000},"page":"646-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of tenofovir disoproxil fumarate and telbivudine in preventing hepatitis B transmission in mothers with high viral load"],"prefix":"10.1002","volume":"160","author":[{"given":"Ming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital Capital Medical University\/Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-7478","authenticated-orcid":false,"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00487.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.2.36"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.060"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01492.x"},{"key":"e_1_2_9_6_1","first-page":"CD004790","article-title":"Hepatitis B immunisation for newborn infants of hepatitis B surface antigen\u2010positive mothers","volume":"19","author":"Lee C","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_9_8_1","unstructured":"World Health Organization Western Pacific Regional Office.Eliminating Mother to Child Transmission of HIV Hepatitis and Syphilis. 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