{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:32Z","timestamp":1791821132877,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study obstetric outcomes of a second pregnancy among women with a first ectopic pregnancy (EP) treated with methotrexate compared with laparoscopic salpingectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study including all women with a first EP and a following pregnancy that concluded by delivery at \u226524\u2009weeks of gestation between March 2011 and April 2021. Second pregnancy outcomes were compared between women treated with methotrexate and those treated with salpingectomy in their first pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 125 women were included, of which 64 (51.2%) were treated with methotrexate and 61 (48.8%) were treated with salpingectomy. In women treated with salpingectomy, the proportion of women conceiving by in vitro fertilization and those with measured gestational sac diameter or \u03b2\u2010subunit human chorionic gonadotropin was higher. The proportion of women conceiving by in vitro fertilization in their second pregnancy was higher in the salpingectomy group (55.2% versus 18.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). All maternal and neonatal outcomes were similar in both groups.<\/jats:p><jats:p>The rate of low birth weight\u2009&lt;\u20092500\u2009g was 7.8% in the methotrexate group versus 18% in the salpingectomy group (<jats:italic>P<\/jats:italic>\u00a0=\u20090.111).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal and neonatal outcomes of a second pregnancy among women treated for EP in their first pregnancy are similar in women treated by methotrexate and those treated by salpingectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14365","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T03:33:15Z","timestamp":1658719995000},"page":"823-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ectopic first pregnancy treated by methotrexate versus salpingectomy\u2014Maternal and perinatal outcomes in a subsequent pregnancy: A retrospective study"],"prefix":"10.1002","volume":"160","author":[{"given":"Gabriel","family":"Levin","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviran","family":"Ohayon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine St. George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Weissbach","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel\u2010Aviv\u2010Hebrew University  Tel\u2010Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Chaim Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechiel Z.","family":"Burke","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel\u2010Aviv\u2010Hebrew University  Tel\u2010Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Chaim Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0720-4343","authenticated-orcid":false,"given":"Raanan","family":"Meyer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel\u2010Aviv\u2010Hebrew University  Tel\u2010Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Chaim Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"The Dr. Pinchas Bornstein Talpiot Medical Leadership Program, Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"issue":"10","key":"e_1_2_10_2_1","first-page":"599","article-title":"Ectopic pregnancy: diagnosis and management","volume":"101","author":"Hendriks E","year":"2020","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000492"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000324.pub2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)05487-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des375"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.03.019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001243"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1437411"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31817d201e"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.02.018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002464"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12633"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.06.013"}],"container-title":["International Journal of Gynecology &amp; 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