{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:12:50Z","timestamp":1747149170661,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of an estrogen replacement regimen on frozen embryo transfer (FET) cycle outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present retrospective cohort study, data of infertile women undergoing FET with good\u2010quality embryos were reviewed. The first group received 2\u2009mg of estradiol hemihydrate (EH) once daily for 6 to 7\u2009days, then twice daily for 4 to 5\u2009days, and then three times a day until embryo transfer. The second group received EH twice daily for 7 to 8\u2009days, then three times a day. The third group received EH three times a day constantly. The main outcome measure was live birth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 394 FET cycles were included. The fixed 6\u2010mg group required the highest estradiol hemihydrate dose. The duration of estrogen treatment was significantly longer in the first group. Maximal endometrial thickness was highest in the second group (10.2\u00a0\u00b1\u20091.3\u2009mm vs. 9.6\u00a0\u00b1\u20091.4\u2009mm vs. 8.6\u00a0\u00b1\u20090.9\u2009mm, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). The clinical pregnancy rates in the groups were 41.1%, 55.2%, and 42.2%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u20090.035). Live birth rates were 40.8%, 50.9%, and 48.1%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u20090.320).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In FET cycles with hormone replacement therapy, a step\u2010up 4\u2010mg regimen provides thicker endometrium with optimal\u2010dose estrogen in an adequate time frame. The tendency for increased clinical pregnancy and live birth rates is remarkable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14366","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T14:48:15Z","timestamp":1658587695000},"page":"829-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of an estrogen replacement regimen on live birth rate in frozen\u2013thawed good\u2010quality embryo transfer"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-3522","authenticated-orcid":false,"given":"Yavuz Emre","family":"\u015e\u00fck\u00fcr","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batuhan","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batuhan","family":"\u00d6zmen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"S\u00f6nmezer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"Berker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem Somer","family":"Atabeko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru\u015fen","family":"Ayta\u00e7","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MEETUP Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1093\/humrep\/deaa250"},{"volume-title":"2018 Assisted Reproductive Technology Fertility Clinic Success Rates Report","year":"2020","author":"Centers for Disease Control and Prevention","key":"e_1_2_10_3_1"},{"key":"e_1_2_10_4_1","first-page":"233","article-title":"Assisted reproductive Technology in Europe, 2011: results generated from European registers by ESHRE","volume":"31","author":"European IVFMC, European Society of Human Reproduction and Embryology","year":"2016","journal-title":"Hum Reprod"},{"unstructured":"WeissmanA.IVF Worldwide Survey Results: Frozen\u2010Thawed Embryo Transfer.2017. 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