{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:58:18Z","timestamp":1771649898511,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1315504"],"award-info":[{"award-number":["2018YFC1315504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81761128006"],"award-info":[{"award-number":["81761128006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773533"],"award-info":[{"award-number":["81773533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To address the value of visual inspection where HPV\u2010based screening is not yet available, we evaluated the real\u2010world effectiveness of visual inspection with acetic acid (VIA) and with Lugol's iodine (VILI) as a primary screening method for cervical cancer in rural China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 206\u2009133 women aged 30\u201359\u2009years received two rounds of VIA\/VILI screening for cervical cancer in 2006\u20132010. Women with positive screening results underwent colposcopy and direct biopsy, and were treated if cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was diagnosed. Clinical effectiveness of VIA\/VILI was evaluated by process and outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The VIA\/VILI positivity rate, biopsy rate and detection rate of CIN2+ in the second round were significantly lower than in the first round. The 2\u2010year cumulative detection rate of CIN2+ varied from 0.53% to 0.90% among the four cohorts initiated in 2006, 2007, 2008, and 2009. The first round of screening detected 60%\u201383% of CIN2, 70%\u201386% of CIN3, and 88%\u2013100% of cervical cancer. Over 92% of CIN2+ were found at the early stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multiple rounds of visual inspection with continuous training and quality assurance could act as a temporary substitutional screening method for cervical cancer in resource\u2010restricted settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14368","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T12:54:07Z","timestamp":1658667247000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Implementation of visual inspection with acetic acid and Lugol's iodine for cervical cancer screening in rural China"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-1612","authenticated-orcid":false,"given":"Shang\u2010Ying","family":"Hu","sequence":"first","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-018X","authenticated-orcid":false,"given":"Xue\u2010Lian","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-0005","authenticated-orcid":false,"given":"Fang\u2010Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayinuer","family":"Niyazi","sequence":"additional","affiliation":[{"name":"People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Cancer Hospital &amp; Institute  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangxi Maternal and Child Health Hospital  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Dong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian\u2010Zhi","family":"Duan","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Sauvaget","sequence":"additional","affiliation":[{"name":"Early Detection, Prevention and Infections Branch International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-0871","authenticated-orcid":false,"given":"You\u2010Lin","family":"Qiao","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rengaswamy","family":"Sankaranarayanan","sequence":"additional","affiliation":[{"name":"Research Triangle Institute, International\u2010India  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"FerlayJ ErvikM LamF et al.Global cancer observatory: cancer today. 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