{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:56:10Z","timestamp":1783130170555,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate two different gonadotropin\u2010releasing (pituitary downregulating) hormones used in in vitro fertilization (IVF) on the live birth rate in young patients with low body mass index (BMI) undergoing their first IVF cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study in a single public medical center, 555 long gonadotropin\u2010releasing hormone agonist (GnRH\u2010a) protocols were compared with 431 prolonged GnRH\u2010a protocols between 2016 and 2018. All analyses were performed using the SPSS version 22.0. The primary measured outcome was live birth rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the long protocol, the prolonged protocol required more doses of gonadotropin and a longer duration of ovarian stimulation. Lower levels of serum luteinizing hormone and serum estrogen were detected on the day of chorionic gonadotropin administration, and a lower fertilization rate was found in the prolonged protocol. Although more oocytes were retrieved and more frozen embryos were recorded in the prolonged protocol, the live birth rate per fresh cycle was comparable between the two protocols (<jats:italic>P<\/jats:italic>\u00a0=\u20090.057). The incidence of ovarian hyperstimulation syndrome was higher in the prolonged protocol group. In the subgroup of women with antral follicle count (AFC) of 12 or less, there was no difference in the live birth rate between the two protocols (<jats:italic>P<\/jats:italic>\u00a0=\u20090.688). However, for women with AFC\u2009&gt;\u2009greater than 12, the prolonged protocol was still a positive predictor of live birth rate. The odds ratio was 1.73 (95% confidence interval 1.04\u20132.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prolonged protocol might not increase the live birth rate in women with low BMI who are undergoing their first IVF cycle. However, for women with AFC greater than 12, a prolonged protocol could be a good choice to improve the live birth rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14373","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T12:44:56Z","timestamp":1659012296000},"page":"850-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of two gonadotropin\u2010releasing hormone agonist suppression protocols for in vitro fertilization in young patients with low body mass index"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-9045","authenticated-orcid":false,"given":"Xin","family":"Mu","sequence":"first","affiliation":[{"name":"The Assisted Reproductive Medicine Center Northwest Women's and Children's Hospital  Xi'an Shaanxi China"},{"name":"Center for Translational Medicine The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Cai","sequence":"additional","affiliation":[{"name":"The Assisted Reproductive Medicine Center Northwest Women's and Children's Hospital  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u2010zi","family":"Shi","sequence":"additional","affiliation":[{"name":"The Assisted Reproductive Medicine Center Northwest Women's and Children's Hospital  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14966"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2016.1147546"},{"issue":"11","key":"e_1_2_9_4_1","first-page":"CD006919","article-title":"Gonadotrophin\u2010releasing hormone agonist protocols for pituitary suppression in assisted reproduction","volume":"9","author":"Siristatidis CS","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2013.795385"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00571-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.030"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.860121"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163393"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.10.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.10.029"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.028"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"248","article-title":"Ovarian hyperstimulation syndrome: a narrative review of its pathophysiology, risk factors, prevention, classification, and management","volume":"43","author":"Namavar Jahromi BM","year":"2018","journal-title":"Iran J Med Sci"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303499"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-017-0457-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7272.1320"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh374"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.11.027"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03373-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118756753"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2769"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-014-0100-8"},{"key":"e_1_2_9_23_1","first-page":"1","article-title":"The effect of maternal body mass index (BMI) and telomere function on in vitro fertilization (IVF) outcome: a preliminary cohort study","volume":"17","author":"Weeg N","year":"2019","journal-title":"Hum Fertil (Camb)"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1528221"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133887"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.144106"}],"container-title":["International Journal of Gynecology &amp; 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