{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:25:45Z","timestamp":1771550745639,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the changes in (1) residual myometrial thickness (RMT), (2) cesarean scar defect (CSD) size, and (3) clinical symptoms, before and after channel\u2010like (360\u00b0) hysteroscopic resection for the treatment of CSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center, observational, prospective, cohort study was carried out enrolling all symptomatic patients of childbearing age, diagnosed with CSD and routinely scheduled for channel\u2010like (360\u00b0) hysteroscopic resection from July 2020 to July 2021 at the Division of Gynecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero\u2010Univeristaria di Bologna. University of Bologna, Italy. The primary outcome was the difference in mean RMT before and after the procedure. Secondary outcomes were the differences before and 4\u00a0months after the surgery in: (1) CSD size measured by transvaginal ultrasound, (2) visual analog scale (VAS) scores for the symptoms, and (3) abnormal uterine bleeding (AUB) rate. Lastly, patients' satisfaction was assessed by the global impression of improvement (PGI\u2010I) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a significant difference before and after the procedure in: (1) mean RMT (+2.0\u2009mm; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001); mean size of the CSD (base: +1.6\u2009mm; height: \u22122.5\u2009mm; transverse diameter: \u22123.2\u2009mm; volume: \u2212263.7\u2009mm<jats:sup>3<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001); (2) mean VAS score for dyspareunia (\u22125.84; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), dysmenorrhea (\u22128.94; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), pelvic pain (\u22122.94; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001); (3) AUB rate (91% vs. 3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). Lastly, the mean PGI\u2010I score\u2009\u00b1\u2009SD was 1.7\u2009\u00b1\u20090.9.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Channel\u2010like (360\u00b0) hysteroscopic resection for the treatment of patients with symptomatic CSD may lead to an increase in RMT, decrease in CSD, and improvement of symptoms after the procedure, with high patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14387","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T14:18:20Z","timestamp":1659709100000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Postoperative morphologic changes of the isthmocele and clinical impact in patients treated by channel\u2010like (360\u00b0) hysteroscopic technique"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-5580","authenticated-orcid":false,"given":"Paolo","family":"Casadio","sequence":"first","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-2333","authenticated-orcid":false,"given":"Antonio","family":"Raffone","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-8180","authenticated-orcid":false,"given":"Andrea","family":"Alletto","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-5642","authenticated-orcid":false,"given":"Francesco","family":"Filipponi","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-4378","authenticated-orcid":false,"given":"Diego","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-3540","authenticated-orcid":false,"given":"Alessandro","family":"Arena","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-8084","authenticated-orcid":false,"given":"Agnese","family":"Virgilio","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampietro","family":"Gubbini","sequence":"additional","affiliation":[{"name":"Department of Gynecology Madre Fortunata Toniolo Clinic  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-1379","authenticated-orcid":false,"given":"Mario","family":"Franchini","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tuscany Health Agency  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Paradisi","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2882-4223","authenticated-orcid":false,"given":"Jacopo","family":"Lenzi","sequence":"additional","affiliation":[{"name":"Section of Hygiene, Public Health and Medical Statistics, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4002-1618","authenticated-orcid":false,"given":"Antonio","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit, Department of Advanced Biomedical Sciences, School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-6389","authenticated-orcid":false,"given":"Antonio","family":"Mollo","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry \"Schola Medica Salernitana\" University of Salerno  Baronissi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-4933","authenticated-orcid":false,"given":"Jos\u00e8","family":"Carugno","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Science Department University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-1333","authenticated-orcid":false,"given":"Renato","family":"Seracchioli","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.06.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2007.10.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199501000-00004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6405"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22911"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.01.037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12542"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7496"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1304829"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"1","article-title":"Cesarean scar thickness in non\u2010pregnant women as a risk factor for uterine rupture","volume":"35","author":"Risager JK","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.01.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2019.04.024"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2020.06.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_2_9_17_1","first-page":"217","volume-title":"ECDEU assessment for psychopharmacology","author":"Guy W","year":"1976"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3283521202"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10009-1369"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13464"},{"issue":"604","key":"e_1_2_9_21_1","first-page":"e1","article-title":"Lower uterine segment thickness to prevent uterine rupture and adverse perinatal outcomes: a multicenter prospective study","volume":"215","author":"Jastrow N","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"253","key":"e_1_2_9_22_1","first-page":"e1","article-title":"Evaluation of the usefulness of ultrasound measurement of the lower uterine segment before delivery of women with a prior cesarean delivery: a randomized trial","volume":"226","author":"Rozenberg P","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4245-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.06.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2012.12.006"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.03.012"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2021.2003310"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2014.09.011"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2004.12.023"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2012.03.010"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.05.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.11.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12738"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14733"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2016.04.011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356961"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.10.016"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1999.18.1.13"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.11.038"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0081"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.04.007"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.01.033"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2019.05.013"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T10:44:35Z","timestamp":1692441875000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ijgo.14387"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14387","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"assertion":[{"value":"2022-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}