{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:45:41Z","timestamp":1787867141331,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the correlation between standard laboratory indicators at admission and severe maternal complications due to placental abruption (PA) with intrauterine fetal death (IUFD) after 24\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study in three French tertiary referral hospitals. Correlation of laboratory indicators at admission (platelet count, prothrombin, activated partial thromboplastin time, fibrinogen) and severe maternal complications (massive transfusion, multiple organ failure, hysterectomy, or maternal deaths) in patients with PA and IUFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 12\u2009years, we identified 27\/344 (7.8%) pregnant women presenting PA with IUFD. No patient had coagulopathy at admission. Fifteen individuals (55.5%) underwent delivery by cesarean section before or during labor. Fifteen individuals (55.5%) presented severe complications, and 17\/27 (63%) lost more than 1\u00a0L of blood during delivery. Fibrinogen level was shown to be the laboratory indicator most correlated with severe complications (<jats:italic>r<\/jats:italic>\u00a0=\u2009\u22120.52, <jats:italic>P<\/jats:italic>\u00a0=\u20090.01). The receiver operating characteristic curve of fibrinogen less than 1.9\u00a0g\/L in the prediction of severe complications (area under the curve\u00a0=\u00a00.80, 95% confidence interval [CI] 0.54\u20130.97) showed both a sensitivity and specificity of 83% (95% CI 54%\u201396%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cases of IUFD with PA, fibrinogen levels at admission had a prognostic value for the prediction of severe maternal complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14417","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T08:14:52Z","timestamp":1660983292000},"page":"900-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-2083","authenticated-orcid":false,"given":"Anthony","family":"Atallah","sequence":"first","affiliation":[{"name":"Femme M\u00e8re Enfant University Hospital, Department of Maternal\u2010Fetal Medicine and Obstetric Emergency Department Hospices Civils de Lyon  Bron France"},{"name":"Claude Bernard University Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Piccin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology North\u2010West Hospital of Villefranche\u2010sur\u2010Sa\u00f4ne  Gleize France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Dubernard","sequence":"additional","affiliation":[{"name":"Claude Bernard University Lyon 1  Lyon France"},{"name":"Croix Rousse University Hospital \u2010 Department of Obstetrics and Gynecology Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Jo","family":"Abdul\u2010Hay","sequence":"additional","affiliation":[{"name":"University of Toronto\u2014St. George Campus  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Cortet","sequence":"additional","affiliation":[{"name":"Claude Bernard University Lyon 1  Lyon France"},{"name":"Croix Rousse University Hospital \u2010 Department of Obstetrics and Gynecology Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Huissoud","sequence":"additional","affiliation":[{"name":"Femme M\u00e8re Enfant University Hospital, Department of Maternal\u2010Fetal Medicine and Obstetric Emergency Department Hospices Civils de Lyon  Bron France"},{"name":"Claude Bernard University Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-100106969"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-06-0386"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes096"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02297.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2010.01030.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599149"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000239439.04364.9a"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07600.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198528010-00003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199508000-00026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03460.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90363-v"},{"key":"e_1_2_8_15_1","first-page":"385","article-title":"Abruptio placentae; dangers of delay in delivery","volume":"3","author":"Page EW","year":"1954","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13536"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-018-1638-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13788"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003247"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13285"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.03.019"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-461"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T04:25:31Z","timestamp":1692246331000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/ijgo.14417"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14417","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,3]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}