{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:10:29Z","timestamp":1793693429627,"version":"4.5.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the association between obstetric factors or outcomes and fetal heart rate (FHR) abnormalities after combined spinal\u2010epidural analgesia (CSEA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with singleton term deliveries who received CSEA at our institution between January 1 and December 31, 2017, were analyzed using medical records. We performed a logistic regression analysis to compare factors and outcomes between cases with and without new FHR abnormalities within 1\u00a0h after CSEA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 393 women, 163 showed the new occurrence of FHR abnormality after CSEA. Rupture of the membrane (odds ratio [OR] 2.49; 95% confidence interval [CI] 1.52\u20134.09; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01) and dilatation of the cervix (OR 1.24; 95% CI 1.07\u20131.44; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01) were significantly associated with FHR abnormalities. There were significant differences in FHR abnormality rates between women with cervical dilatation of 2\u00a0cm or less and 3\u00a0cm or more (OR 2.20; 95% CI 1.01\u20134.81; <jats:italic>P<\/jats:italic>\u00a0=\u20090.047) and 6\u00a0cm or less and 7\u00a0cm or more (OR 2.46; 95% CI 1.01\u20136.01; <jats:italic>P<\/jats:italic>\u00a0=\u20090.048). FHR abnormalities were not significantly associated with cesarean delivery during labor, instrumental delivery, APGAR score below 7 at 1 or 5\u00a0min, or umbilical arterial blood gas pH less than 7.2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rupture of the membrane and an advanced dilated cervix were risk factors for FHR abnormality when CSEA was initiated.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14421","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T08:19:17Z","timestamp":1660983557000},"page":"892-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Labor risk factors for fetal heart rate abnormality after combined spinal\u2010epidural analgesia"],"prefix":"10.1002","volume":"160","author":[{"given":"Yoshiko","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Health Policy National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6222-3942","authenticated-orcid":false,"given":"Nagayoshi","family":"Umehara","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Obstetric Anesthesia, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Obstetric Anesthesia, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Health Policy National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.09.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.srhc.2012.10.004"},{"key":"e_1_2_9_4_1","unstructured":"NHS Digital.NHS Maternity Statistics England 2020\u20102021. 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