{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:16:58Z","timestamp":1789150618381,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether abnormal uterine artery Doppler ultrasound during weeks 21\u201323 of pregnancy was associated with an increased risk of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our retrospective cohort study analyzed uterine artery ultrasound parameters in singleton pregnant women at 21\u201323\u2009weeks of pregnancy and assessed the association between abnormal ultrasound findings and the risk of pre\u2010eclampsia. Multivariate logistic regression analysis was conducted to estimate the relative risk between uterine artery ultrasound and pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with normal results, unilateral pulsatile index abnormality (odds ratio [OR] 2.3, 95% confidence interval [CI] 1.71\u20133.10), bilateral pulsatile index anomalies (OR 6.21, 95% CI 3.53\u201310.95), unilateral resistance index abnormality (OR 2.36, 95% CI 1.75\u20133.17), bilateral resistance index anomalies (OR 2.83, 95% CI 1.27\u20136.32), unilateral notch (OR 3.66, 95% CI 2.03\u20136.62), bilateral notch (OR 5.80, 95% CI 3.30\u201310.20) were associated with pre\u2010eclampsia. For every 0.1 increase in the median multiple of mean pulsatile index, the risk of pre\u2010eclampsia increased by 13%; for every 0.1 increase in the median multiple of mean resistance index, the risk of pre\u2010eclampsia increased by 22%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multiples of the median for the pulsatile and resistance indices are an effective evaluation tool. Abnormal uterine artery ultrasound indices are strongly associated with the development of pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14435","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T01:20:45Z","timestamp":1662081645000},"page":"264-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Abnormal uterine artery Doppler ultrasound during gestational 21\u201323\u2009weeks associated with pre\u2010eclampsia"],"prefix":"10.1002","volume":"161","author":[{"given":"Meng","family":"Li","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-0166","authenticated-orcid":false,"given":"Chaoyan","family":"Yue","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03776-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.11.008"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"American College of Obstetricians and Gynecologists: Hypertension in pregnancy","volume":"219","year":"1996","journal-title":"ACOG Tech Bull"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12371"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117187"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7628"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.154"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15873"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082653"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-20938-3_1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2009.08.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMRH.S24048"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070430"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00946-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1575804"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2015.1096371"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31826af7fb"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.7.1265"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1183631"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503963"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.11.009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004251"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.10.036"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-72032013000800004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"}],"container-title":["International Journal of Gynecology &amp; 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