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Guideline quality was assessed using a modified AGREE\u2010II instrument and the AGREE\u2010REX tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Out of 48 statements on the prevention of pre\u2010eclampsia, 46 had recommendations on use of aspirin. Of them, 39 were supported by evidence from systematic reviews or randomized controlled trials. Three statements reported aspirin's significant reductions in preterm pre\u2010eclampsia and one in perinatal death. Concerning quality, 41% of statements were rated as high quality in all domains of the AGREE\u2010II tool, 15% were rated high quality in all domains of the AGREE\u2010REX tool, and 11% were rated high quality in all domains on both tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While 96% of statements advocated for use of aspirin, only 9% reported a significant reduction in preterm pre\u2010eclampsia or perinatal death. 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