{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:01:33Z","timestamp":1782910893044,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate clinical performance and diagnostic accuracy of urinary HPV for non\u2010invasive screening of high\u2010grade precancerous and cancerous cervical lesions in a visual inspection under acetic acid (VIA) \u2010positive cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study included 180 women aged 35\u201365\u2009years, who were VIA positive in a colposcopy clinic. All participants had the initial stream of a random urine sample tested for the presence of high\u2010risk HPV (hrHPV) types 16 and 18 and acetowhite lesions were biopsied per protocol. Concordance analysis was conducted to assess agreement between detection of hrHPV in urine and the presence of premalignant and malignant lesions in cervix on histopathology. Measures of diagnostic accuracy were estimated to evaluate the performance of urinary HPV against histopathology (reference standard).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Substantial agreement between urinary HPV detection and histopathology was found (Cohen's \u03ba is 0.696, <jats:italic>P<\/jats:italic>\u00a0\u2264\u20090.001), with an agreement in 88.9% of the cases and disagreement in 11.1%. The diagnostic performance of urinary HPV in predicting the presence of a high\u2010grade precancerous or cancerous lesion was as follows: sensitivity 67%, specificity 97%, positive predictive value 89%, and negative predictive value 88.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV DNA detection from urine has good concordance with the histopathology for detection of precancerous and cancerous lesions of the cervix. Further studies on optimization of urine sampling and processing techniques are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14486","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T02:47:40Z","timestamp":1664765260000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Study to determine efficacy of urinary <scp>HPV<\/scp> 16 &amp; <scp>HPV<\/scp> 18 detection in predicting premalignant and malignant lesions of uterine cervix"],"prefix":"10.1002","volume":"161","author":[{"given":"Julie Hansa","family":"John","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-0520","authenticated-orcid":false,"given":"Ajay","family":"Halder","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Purwar","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameshwarachari","family":"Pushpalatha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankhuri","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO guideline for screening and treatment of cervical pre\u2010cancer lesions for cervical cancer prevention [Internet]. 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