{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:13:09Z","timestamp":1747149189027,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the feasibility of using ductus venosus Doppler (DVD) to time delivery in early\u2010onset fetal growth restriction (FGR) and pre\u2010eclampsia in a resource\u2010constrained setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, observational study of pregnancies affected by early\u2010onset FGR and pre\u2010eclampsia. Patient characteristics, risk factors, ultrasound findings, and pregnancy outcomes were entered into a data collection tool. The association of these variables with perinatal and maternal outcomes were determined using binary logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study had 61 participants. Most patients were delivered at 29\u201331<jats:sup>+6<\/jats:sup> weeks of pregnancy (67%). Neonates with an estimated fetal weight on ultrasound of less than 800\u2009g had the highest incidence of perinatal mortality (63%). There was a near six\u2010fold increase in risk of major neonatal morbidity in patients with abnormal DVD (odds ratio 5.9, 95% confidence interval [CI] 1.8\u201319.0). Absent flow in the DVD a\u2010wave carried a higher risk of perinatal mortality (OR 23.8, 95% CI 1.7\u2013334.8); 22% of patients with an abnormal DVD a\u2010wave experienced placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Having an abnormal DVD in the background of pre\u2010eclampsia was related to increased perinatal morbidity and mortality, with increased risk of placental abruption.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14495","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T15:09:47Z","timestamp":1665068987000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The pre\u2010eclampsia, growth restriction, and ductus venosus doppler (<scp>GRADED<\/scp>) study: An observational study of early\u2010onset fetal growth restriction and pre\u2010eclampsia"],"prefix":"10.1002","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1256-2214","authenticated-orcid":false,"given":"Vaeochan","family":"Govender","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Grey's Hospital  Pietermaritzburg South Africa"},{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thinagrin D.","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Grey's Hospital  Pietermaritzburg South Africa"},{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serantha","family":"Foolchand","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Grey's Hospital  Pietermaritzburg South Africa"},{"name":"Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"GebhardtS RhodaNR OlubunmiA et al.Saving Babies 2014\u20102016 Triennial Report on perinatal mortality in South Africa. pp 26 35.https:\/\/www.westerncape.gov.za\/assets\/departments\/health\/napemmco_triennial_report_2014\u20102016_saving_babies.pdf"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-016-0039-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"18","article-title":"The investigation and Management of the Small\u2013for\u2013Gestational\u2013age Fetus","volume":"31","author":"Robson SC","year":"2013","journal-title":"Green\u2010Top 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