{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:48:31Z","timestamp":1784238511492,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The authors aimed to compare cross\u2010sectional versus longitudinal models for prediction of small\u2010for\u2010gestational age (SGA) neonates among pregnancies with high risk of early pre\u2010eclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective longitudinal study was performed in Hospital Universitari Dexeus, Barcelona. The study population included 390 pregnancies with a high risk of early PE according to the first trimester algorithm. Cross\u2010sectional models combining first trimester risk plus placental growth factor and FMS\u2010like tyrosine kinase 1\/placental growth factor ratio, respectively, were created at 19\u201322, 24\u201326, and 27\u201330\u2009weeks and compared with a model assessing longitudinal changes of these parameters. Models adding mean uterine artery pulsatility index and abdominal circumference were evaluated. SGA neonates were defined as having a birth weight less than the tenth centile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The predictive performance of a model assessing longitudinal changes of angiogenic factors was similar to that of single evaluations at the second and early third trimesters. The performance of the models combining angiogenic factors with mean uterine artery pulsatility index and abdominal circumference was better than those using only biochemical markers. However, the longitudinal evaluation of biochemical and biophysical parameters did not perform better than cross\u2010sectional evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evaluation of angiogenic factors are useful for prediction of SGA neonates in a high\u2010risk population for early PE. However, longitudinal models do not increase their predictive capacity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14508","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T06:48:12Z","timestamp":1665730092000},"page":"439-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Angiogenic factors assessment in pre\u2010eclampsia high\u2010risk population for the prediction of small\u2010for\u2010gestational age neonates: A prospective longitudinal study"],"prefix":"10.1002","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-6420","authenticated-orcid":false,"given":"Raquel","family":"Mula","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Prats","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Scazzocchio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer Hospital Universitari Dexeus  Barcelona Spain"},{"name":"Atenci\u00f3 a la Salut Sexual i Reproductiva (ASSIR) de Barcelona Institut Catal\u00e0 de la Salut  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproduction, Dexeus Mujer Hospital Universitari Dexeus  Barcelona Spain"},{"name":"Institut Cl\u00ednic de Ginecologia Obstetr\u00edcia i Neonatologia Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.02.016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2010.486460"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701830480"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160819009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802034545"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5315"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.12.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19077"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.12.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14817"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14811"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15919"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.08.040"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4418"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15978"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18894"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14899"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14904"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15740"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12804"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.04.247"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23730"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.03.021"}],"container-title":["International Journal of Gynecology &amp; 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