{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:34Z","timestamp":1786977934637,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672581"],"award-info":[{"award-number":["81672581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701420"],"award-info":[{"award-number":["81701420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the recurrence rate and risk factors between conservative surgery followed by medical treatments and conservative surgery\u2010only in patients with focal adenomyosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was conducted in a single teaching hospital from May 2011 to October 2016. All eligible patients were identified into three groups: surgery\u2010only group, surgery combined with gonadotropin\u2010releasing hormone agonist (GnRHa), and a levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS) group. The recurrence rate and risk factors were compared among groups using Kaplan\u2013Meier and Cox proportional hazards analyses. Receiver operating characteristic (ROC) curve analysis was applied to determine a cut\u2010off value for identifying recurrence\u2010related risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 249 postoperative patients with adenomyosis were included in the final analysis with a mean of 41\u2009months of follow up. The recurrence rate at the long\u2010term follow up was significantly lower in intervention groups than in the surgery\u2010only group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.011). The Cox proportional hazards and ROC analyses showed that a menstrual cycle longer than 26\u2009days (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.026), diameter of lesions &lt;6\u00a0cm (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.030), and combination treatment using GnRHa (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.039) or LNG\u2010IUS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.007) were protective against relapse. The risk of recurrence was lower in patients with anterior (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.034) or fundus (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.038) adenomyosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postoperative therapy using GnRHa or LNG\u2010IUS decreases the long\u2010term relapse rate in women undergoing conservative surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.14561","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T10:04:21Z","timestamp":1667642661000},"page":"594-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of recurrence rate and risk factors in patients with focal adenomyosis with and without medical treatment after conservative surgery"],"prefix":"10.1002","volume":"161","author":[{"given":"Wenwen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Affiliate Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldx027"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.4.323"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.032"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1744"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.953055"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55703-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.13.1.119"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2015.05.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.02.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.01.017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.07.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2012.04.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2012.12.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.01.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13609"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.12.036"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002922"},{"issue":"3","key":"e_1_2_9_21_1","first-page":"3430","article-title":"Recurrence\u2010associated factors of laparoscopic adenomyomectomy for severely symptomatic adenomyoma","volume":"16","author":"Yu W","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/172460080702200306"}],"container-title":["International Journal of Gynecology &amp; 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