{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:38:21Z","timestamp":1784255901662,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the influence of respiratory allergy on obstetrics and perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested case\u2013control retrospective study on 41\u2009035 pregnant women. Obstetrics and perinatal outcomes of women with or without respiratory allergy were compared. Rates of preterm delivery (&lt;37\u2009weeks of gestation), low birth weight (&lt;2500\u2009g), neonatal acidosis (pH\u2009&lt;\u20097.20), low 5\u2010min APGAR score (&lt;7), cesarean section rate and indications, and perinatal morbidity and mortality were analyzed. Results are expressed as number and percentages. \u03c7<jats:sup>2<\/jats:sup> and Fisher exact tests were used for comparisons. Logistic regression was used. Statistical significance was set at 95% level (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 724 (1.8%) patients had respiratory allergy, and their rates of preterm delivery and low birth weight were significantly higher than those of control women (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). Nevertheless, analyzing the causes, multiple gestation rate was significantly higher in this group, and adjusting by this, no statistical difference was found in any of the perinatal outcomes studied. In addition, in vitro fertilization and sterility were also significantly higher in the respiratory allergy group (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with respiratory allergy are at higher risks of prematurity and low birth weight but these results are mediated by sterility, in vitro fertilization, and multiple gestation rate. Nonetheless, participation of inflammatory mechanisms should be further studied.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14562","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T14:18:33Z","timestamp":1667657913000},"page":"509-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The influence of maternal respiratory allergy on obstetrics and perinatal outcomes: A nested case\u2013control study"],"prefix":"10.1002","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-4131","authenticated-orcid":false,"given":"Irene","family":"Bartha","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London and Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Faculty of Medicine Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Life Sciences and Medicine King's College London and Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de la Calle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Martin Boado","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Martinez\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-9690","authenticated-orcid":false,"given":"Jose Luis","family":"Bartha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"},{"name":"Department of Obstetrics and Gynecology University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.03.036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2019.89501"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12154"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.11.035"},{"key":"e_1_2_9_6_1","first-page":"122","volume-title":"Alergol\u00f3gica 2015","author":"Dordal Culla MT","year":"2015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01691-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02025"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13497"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12802"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55259-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S203576"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00148713"},{"key":"e_1_2_9_14_1","unstructured":"World Health Organization. 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