{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:20:36Z","timestamp":1780564836893,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the high\u2010risk factors of ovarian metastasis of endometrial cancer and their impact on prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2013control study was conducted on a large cohort of patients with endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1240 patients with endometrial cancer were eligible for analysis, of whom 120 (9.7%) had ovarian metastasis. The patients with endometrial cancer with ovarian metastasis were more likely to have deep myometrial infiltration, lymph node metastasis, and elevated levels of CA125. The median survival was 39\u2009months in patients with ovarian metastasis and 111\u2009months in those without ovarian metastasis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). According to the stratified analysis, the progression\u2010free survival (PFS) and overall survival in the low\u2010risk group and PFS in the high\u2010risk group of patients with endometrial cancer with ovarian metastasis were significantly shorter than those without ovarian metastasis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001, <jats:italic>P<\/jats:italic>\u00a0=\u20090.0034, and <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Deep myometrial invasion, lymph node metastasis, and elevated levels of CA125 may be independent high\u2010risk factors for ovarian metastasis in patients with endometrial cancer. Ovarian metastasis has a greater impact on the prognosis of patients with low\u2010risk endometrial cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14606","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:44:49Z","timestamp":1669898689000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of high\u2010risk factors for ovarian metastasis in patients with endometrial cancer: A large\u2010sample retrospective case\u2013control study"],"prefix":"10.1002","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-9150","authenticated-orcid":false,"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology Cancer Hospital of China Medical University\/Liaoning Cancer Hospital &amp; Institute  Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Cancer Hospital of China Medical University\/Liaoning Cancer Hospital &amp; Institute  Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30349"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_175666"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00130-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.01.030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002142"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001181"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2014.05.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000576"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j372"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-2109-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67063-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy167"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01354.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.06.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1733-2"},{"key":"e_1_2_9_17_1","first-page":"352","article-title":"Study of the risk factors for ovarian metastasis in patients with endometrial carcinoma","volume":"43","author":"Li LY","year":"2008","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2628-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2019.30.e70"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001300"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.928826"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"e_1_2_9_23_1","first-page":"596","article-title":"Clinical application of TCGA molecular classification in endometrial endometrioid carcinoma","volume":"48","author":"Du NN","year":"2019","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001020"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:48:57Z","timestamp":1692694137000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/ijgo.14606"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14606","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]},"assertion":[{"value":"2022-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}