{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:37:41Z","timestamp":1788910661946,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To synthesize the evidence from randomized controlled trials (RCTs) of antihypertensive treatment for mild pregnancy hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched various databases from inception to June 2022, using keywords including hypertension; pregnancy; therapy; treatment; pregnancy outcomes; maternal outcomes; and perinatal outcomes. Only RCTs of antihypertensive treatment for mild hypertension in pregnancy comparing placebo\/no therapy were included. We used Review Manager version 5.3 for statistical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, eight studies were eligible, with a total of 4211 participants. Compared with control, the active treatment significantly prevented preeclampsia (OR 0.55; 95%CI, 0.39\u20130.78), placental abruption (OR 0.39; 95%CI, 0.17\u20130.91), severe hypertension (OR 0.35; 95%CI, 0.17\u20130.71), end\u2013organ dysfunction (OR 0.34; 95%CI, 0.19\u20130.62) and preterm birth (OR 0.69; 95%CI, 0.59\u20130.82), with no increased risk of small for gestational age (SGA) (OR 1.25; 95%CI, 0.78\u20132.00), or admission to the NICU (OR 0.83; 95%CI, 0.54\u20131.28). Subgroup analyses demonstrated that the tight control group did not show an advantage over the less\u2010tight control group in improving pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In pregnant women with mild pregnancy\u2010induced hypertension or chronic hypertension, antihypertensive treatment still provided precise benefits of improving pregnancy outcomes without increased risk in fetal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14634","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T08:54:43Z","timestamp":1671353683000},"page":"202-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment for mild hypertension in pregnancy with different strategies: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-0002","authenticated-orcid":false,"given":"Zhichao","family":"Chen","sequence":"first","affiliation":[{"name":"University of Sassari  Sassari Italy"},{"name":"Department of Life Science and Biotechnology Second Affiliated Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Sassari  Sassari Italy"},{"name":"Department of Life Science and Biotechnology Second Affiliated Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciriaco","family":"Carru","sequence":"additional","affiliation":[{"name":"University of Sassari  Sassari Italy"},{"name":"Department of Biomedical Sciences Second Affiliated Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youren","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-5612","authenticated-orcid":false,"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32335-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2015-205483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nwh.2020.02.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9762-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008337"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08049-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00113-X"},{"key":"e_1_2_9_15_1","first-page":"CD002252","article-title":"Antihypertensive drug therapy for mild to moderate hypertension during pregnancy","volume":"2018","author":"Abalos E","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13809"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12253"},{"key":"e_1_2_9_19_1","unstructured":"HigginsJ GreenS.Cochrane handbook for systematic reviews of interventions. 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