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A total of 190 patients with severe adenomyosis underwent uterus\u2010sparing surgery between January 2010 and June 2020. Of these patients, 90 were analyzed. Forty\u2010six patients (control group) received adjuvant 6\u2010month GnRH\u2010a therapy alone after uterus\u2010sparing surgery, and 44 patients (maintenance group) received postoperative 6\u2010month GnRH\u2010a treatment followed by maintenance DNG therapy (2\u00a0mg\/day orally). The median follow\u2010up period was 18\u2009months. The study was analyzed using generalized estimating equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, the characteristics of patients in each group were comparable. Compared with the control group, the maintenance group had a significant improvement in the visual analog scale score of dysmenorrhea (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), hemoglobin level (<jats:italic>P<\/jats:italic>\u00a0=\u20090.004), and uterine volume (<jats:italic>P<\/jats:italic>\u00a0=\u20090.004) from baseline to 18\u2009months after uterus\u2010sparing surgery. The symptom recurrence rate was significantly lower in the maintenance group than in the control group (4.6% vs. 37.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study suggest that combinatorial treatment with GnRH\u2010a (adjuvant treatment) and DNG (maintenance therapy) represents a safe and effective short\u2010term therapy after uterus\u2010sparing surgery for adenomyosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14635","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T07:05:08Z","timestamp":1671260708000},"page":"751-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maintenance dienogest therapy following adjuvant gonadotropin\u2010releasing hormone agonist treatment after uterus\u2010sparing surgery in adenomyosis: A retrospective cohort 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