{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:31:25Z","timestamp":1790875885876,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the maternal and perinatal outcomes in women with severe pre\u2010eclampsia before 28\u2009weeks of pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A descriptive study from a tertiary care center. All consecutive women with severe pre\u2010eclampsia withonset before 28\u2009weeks of pregnancy were included. The details were collected in a predesigned structured proforma prospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort included 145 women with a mean maternal age of 26.97\u2009\u00b1\u20095.36\u2009years (range 19\u201347\u2009years). The mean duration of prolongation of pregnancy was 13.04\u2009\u00b1\u200910.57\u2009days (range 1\u201351\u2009days). A total of 29.7% (\n                      <jats:italic>n<\/jats:italic>\n                      = 43) of women had at least one major adverse maternal outcome, and the most common was HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      = 24,16.6%), followed by eclampsia (\n                      <jats:italic>n<\/jats:italic>\n                      = 12,8.3%). The stillbirth rate was high (\n                      <jats:italic>n<\/jats:italic>\n                      = 103,68.7%), and most occurred in the antepartum period. Of 47 (31.3%) neonates born alive, only eight (17.02%;8\/47) survived up to 28\u2009days of life. Fetal growth restriction with Doppler abnormalities and neonatal sepsis were the most common reasons for perinatal mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Expectant management should not be considered routinely when the onset of severe pre\u2010eclampsia is before 25\n                      <jats:sup>+6<\/jats:sup>\n                      weeks of pregnancy. Between 26 and 27\n                      <jats:sup>+6<\/jats:sup>\n                      weeks it can be offered under close monitoring and the perinatal survival depends on the neonatal services available in their facility.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.14642","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T01:39:37Z","timestamp":1672364377000},"page":"1075-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Maternal and perinatal outcome of women with early\u2010onset severe pre\u2010eclampsia before 28\u2009weeks: Is expectant management beneficial in a low\u2010resource country? A prospective observational study"],"prefix":"10.1002","volume":"161","author":[{"given":"Lekha","family":"Gangadhar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-2039","authenticated-orcid":false,"given":"Sasirekha","family":"Rengaraj","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutharsika","family":"Thiyagalingam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Sir Evan Stedeford hospital  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhisivam","family":"Bethou","sequence":"additional","affiliation":[{"name":"Department of Neonatology JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000589"},{"key":"e_1_2_9_3_1","first-page":"728","volume-title":"Chapter 40; Hypertensive Disorders","author":"Cunningham FG","year":"2014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.14.32"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000250"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.062"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14512"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.03.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246392"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214243"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.076"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.928689"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903168432"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14642","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:58:15Z","timestamp":1692431895000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/ijgo.14642"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14642","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}