{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:50:27Z","timestamp":1692507027209},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The intrauterine contraceptive device TCu380Ag when compared with TCu380A at 1\u2009year of use had better acceptability and continuation rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the continuation rate, efficacy, and acceptability of TCu380Ag in three sizes versus TCu380A at 5\u2009years of use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 600 women opting for intrauterine contraceptive devices were randomized equally into two groups. Group 1 received the TCu380Ag device (Normal, Maxi, and Mini for uterocervical length 7\u20138.5\u00a0cm, 8\u20139\u00a0cm, and 6\u20137.5\u00a0cm, respectively) and Group 2 received the TCu380A device. Follow\u2010up was performed at 5\u2009years to assess efficacy, acceptability, and continuation. Frequency data comparisons was performed across categories using \u03c7<jats:sup>2<\/jats:sup>\/Fisher exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 5\u2009years of use, Kaplan\u2013Meier survival analysis showed that TCu380Ag compared with TCu380A had a higher continuation rate (45% vs. 35%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.010) with 100% efficacy each. TCu380Ag had fewer side effects, including heavy menstrual bleeding (16.6% vs. 34.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), abdomen pain (12.1% vs. 23.0%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.001), and expulsions (4.4% vs. 8.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.050), and fewer discontinuations attributable to contraceptive side effects (42.7% vs. 56.9%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.012). The mini TCu380Ag had the highest continuation rates and least menstrual irregularity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The TCu380Ag device in three sizes is an alternative to TCu380A for women desiring 5\u2009years of contraception with equal efficacy, better continuation, and acceptability. The mini size is preferred for women with a uterocervical length of 6 to 7.5\u00a0cm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14651","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T18:18:11Z","timestamp":1674065891000},"page":"784-793","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 5\u2010year comparative study of efficacy and acceptability of three different sizes of <scp>TCu380Ag<\/scp> and <scp>TCu380A<\/scp> intrauterine devices"],"prefix":"10.1002","volume":"161","author":[{"given":"Neerja","family":"Bhatla","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohini","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiralal","family":"Konar","sequence":"additional","affiliation":[{"name":"Calcutta National Medical College &amp; Hospital  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achanta","family":"Vivekanand","sequence":"additional","affiliation":[{"name":"Prathima Institute of Medical Sciences  Karimnagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Kriplani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perumal","family":"Vanamail","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. N.","family":"Purandare","sequence":"additional","affiliation":[{"name":"FIGO, Indian College of Obstetricians and Gynaecologists, Purandare Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Medical Eligibility Criteria for Contraceptive Use","author":"World Health Organization","year":"2004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(88)90046-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2012.09.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12809"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31821188ad"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20150431"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(94)90067-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(94)90109-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(90)90046-X"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del208"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del029"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"CD006134","article-title":"Pain relievers for bleeding and pain related to intrauterine devices used for birth control","volume":"2006","author":"Grimes DA","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006034.pub2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00385-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500443667"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13691050902919093"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/16871.7020"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S6914"},{"issue":"1043","key":"e_1_2_11_20_1","first-page":"169","article-title":"The Nova\u2010T 200 intrauterine contraceptive device: a 12 year study","volume":"110","author":"Baeyertz JD","year":"1997","journal-title":"N Z Med J"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1783\/147118906777888279"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91904-m"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:58:22Z","timestamp":1692446302000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/ijgo.14651"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14651","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,7]]},"assertion":[{"value":"2022-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}