{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:05:27Z","timestamp":1771931127833,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize gastrointestinal bubbles detected since early pregnancy and to describe corresponding diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective cohort review of all cases in which gastrointestinal bubbles were detected starting in early prenatal transvaginal scans at 14\u201317\u2009weeks of gestation between the years 2007 and 2021. Sonographic features and data regarding associated anomalies, genetic abnormalities, and pregnancy outcome were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bubbles were detected in 23 of 27\u2009073 early scans and a total of 31\u2009394 scans. Diagnosis was available in 22 cases. Transient bubbles were detected in 10 cases and represented normal peristalsis. Fixed double bubble was detected in nine cases. Double\u2010walled double bubbles represented duodenal duplications (three cases) and esophageal duplications (two cases). Simple cysts represented duodenal atresia (three cases) and a pancreatic cyst (one case). A triple bubble represented duodenal obstruction from Ladd bands in one case. Quadribubble was detected in two cases and represented jejunal atresia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal detection of gastrointestinal bubbles can accurately diagnose physiological versus pathological upper gastrointestinal conditions. Transient bubbles are physiological. Fixed double bubbles might represent either duodenal atresia or esophageal\/duodenal duplications when a double wall is demonstrated. Three or four bubbles might represent more distal intrinsic or extrinsic obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14666","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T17:41:09Z","timestamp":1673631669000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prenatal detection of gastrointestinal bubbles since early pregnancy: Clues to correct diagnosis"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-5438","authenticated-orcid":false,"given":"Osnat","family":"Zmora","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Shamir Medical Center, Zerifin, Be'er Ya'akov, Israel, and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Beloosesky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel, and Rappaport Faculty of Medicine Technion\u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Khatib","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel, and Rappaport Faculty of Medicine Technion\u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel, and Rappaport Faculty of Medicine Technion\u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayala","family":"Gover","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Carmel Medical Center, Haifa, Israel, and Rappaport Faculty of Medicine Technion\u2010 Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Bronshtein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel, and School of Public Health Haifa University  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-007-9211-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2406-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199603)16:3<203::AID-PD830>3.0.CO;2-#"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368603"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(05)80364-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1990.tb01592.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.03.017"},{"key":"e_1_2_8_10_1","first-page":"529","article-title":"Early prenatal diagnosis of double aortic arch: prevalence, associated anomalies and outcome","volume":"42","author":"Zmora O","year":"2020","journal-title":"Ultraschall Med \u2010 Eur J Ultrasound"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199606)16:6<564::AID-PD903>3.0.CO;2-U"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500471"},{"key":"e_1_2_8_13_1","first-page":"71","article-title":"Late third trimester ultrasound diagnosis of duodenal atresia \u2013 the impportance of detailed prenatal ultrasound screenining","volume":"17","author":"Akinmoladun JA","year":"2019","journal-title":"Ann Ib Postgrad Med"},{"key":"e_1_2_8_14_1","first-page":"320","article-title":"The advantages of early midtrimester targeted fetal systematic organ screening for the detection of fetal anomalies\u2013will a global change start in Israel?","volume":"153","author":"Bronshtein M","year":"2014","journal-title":"Harefuah"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjr.2020.95477"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013165"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/131.1.191"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39950"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15029"}],"container-title":["International Journal of Gynecology &amp; 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