{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:18:33Z","timestamp":1776309513377,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate changes in maternal serum midkine levels in pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 40 pregnant women with pre\u2010eclampsia and 66 healthy pregnant women in the control group. Demographic data, laboratory results, and midkine levels were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pre\u2010eclampsia and control groups were similar in terms of demographics. The midkine level of pregnant women with pre\u2010eclampsia was significantly higher than that of the controls (0.54\u2009\u00b1\u20090.23 and 0.31\u2009\u00b1\u20090.19\u2009ng\/mL, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). According to the receiver operating characteristic analysis, the optimal cut\u2010off value of midkine was determined as 0.37\u2009ng\/mL, at which it had 75% sensitivity and 74% specificity (area under the curve: 0.815, 95% confidence interval 0.73\u20130.89, <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The serum midkine level was significantly higher in pregnant women with pre\u2010eclampsia. Midkine seems to be associated with complicated inflammatory processes leading to pre\u2010eclampsia. Further study protocols can be planned to investigate the role of midkine in the prediction of pre\u2010eclampsia as a novel marker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14677","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T14:44:28Z","timestamp":1673880268000},"page":"287-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of serum midkine levels between pregnant women with and without pre\u2010eclampsia: A case\u2013control study from a tertiary hospital"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-5072","authenticated-orcid":false,"given":"Bedri","family":"Sakcak","sequence":"first","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Turkish Ministry of Health Ankara City Hospital  Ankara 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