{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:34:50Z","timestamp":1792809290736,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601276"],"award-info":[{"award-number":["81601276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH012"],"award-info":[{"award-number":["ZR2021MH012"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of the long\u2010acting gonadotropin\u2010releasing hormone agonist (GnRHa) long protocol on in vitro fertilization (IVF) outcomes of patients with endometriosis (EMs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was carried out from July 1, 2016 to June 30, 2021. In all, 798 patients with EMs who underwent first IVF were enrolled. The patients were classified by the ovarian stimulation protocols. The clinical outcomes of IVF were compared in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Those EMs patients who received the long\u2010acting GnRHa long protocol had significantly higher clinical pregnancy rate (72.00%, 60.70% and 50.90%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u20090.047 and 0.010) and implantation rate (51.0%, 44.6%, and 38.7%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u20090.006 and &lt;0.001) compared with the short\u2010acting GnRHa long protocol and the GnRH antagonist protocol. Live birth rate was also significantly higher than the GnRH antagonist protocol (60.10% vs. 40.0%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.032), but not statistically different from the short\u2010acting GnRHa (60.10% vs. 53.80%, <jats:italic>P<\/jats:italic>\u00a0=\u20090.443). In addition, they also had significantly higher duration of stimulation, total dose of gonadotropin, and number of high\u2010quality embryos transferred compared with other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The long\u2010acting GnRHa long protocol could improve IVF outcomes of patients with EMs compared with the short\u2010acting GnRHa long protocol and the GnRH antagonist protocol.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14690","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T10:44:30Z","timestamp":1674470670000},"page":"325-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is the long\u2010acting gonadotropin\u2010releasing hormone agonist long\u00a0protocol better for patients with endometriosis undergoing <scp>IVF<\/scp>?"],"prefix":"10.1002","volume":"162","author":[{"given":"Xiuzhu","family":"Wang","sequence":"first","affiliation":[{"name":"Weifang Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Chen","sequence":"additional","affiliation":[{"name":"Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Yantai Yuhuangding Hospital  Yantai 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