{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:59:29Z","timestamp":1771667969287,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010083","name":"Radford University","doi-asserted-by":"publisher","award":["1021062812133\u20100\u20103.2.2"],"award-info":[{"award-number":["1021062812133\u20100\u20103.2.2"]}],"id":[{"id":"10.13039\/100010083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Attributable to the insulin\u2010like growth factor (IGF) axis involvement in fetal growth regulation, possible contribution of the maternal IGF axis to antenatal fetal macrosomia diagnosis is a subject of particular interest in diabetic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 women were prospectively enrolled in a longitudinal single\u2010center cohort study. The four study groups were: type 1 diabetes (<jats:italic>n<\/jats:italic>\u00a0=\u00a040), type 2 diabetes (<jats:italic>n<\/jats:italic>\u00a0=\u00a035), gestational diabetes (<jats:italic>n<\/jats:italic>\u00a0=\u00a040), and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a015). IGF\u20101 and IGF\u20102 and insulin\u2010like growth factor\u2010binding protein (IGFBP) 1, 3, 6, and 7 serum levels were analyzed in 11\u2010 to 14\u2010week and 30\u2010 to 34\u2010week samples with a specific immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In mothers of large\u2010for\u2010gestational\u2010age neonates (90th percentile), higher (median test) first\u2010trimester IGF\u20101 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and lower IGFBP\u20101 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035) were observed. The IGF\u20101\/IGFBP\u20101 ratio was positively associated with neonatal weight (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.434, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Receiver operating characteristic analysis revealed an association between large for gestational age and the first\u2010trimester IGF\u20101 (area under the curve [AUC]\u00a0=\u00a00.747, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), IGFBP\u20101 (AUC\u00a0=\u00a00.334, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011), and IGF\u20101\/IGFBP\u20101 ratio (AUC\u00a0=\u00a00.750, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). IGF\u20101\/IGFBP\u20101 ratio had better performance for prediction of birth weight over 4000 g (AUC\u00a0=\u00a00.822, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The authors detected different first\u2010trimester IGF\u20101 and IGF\u20101\/IGFBP\u20101 thresholds applicable for either supposition or rejection of macrosomia diagnosis. Further investigation is needed to determine how the maternal IGF axis can contribute to fetal macrosomia prediction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14696","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T07:48:47Z","timestamp":1674892127000},"page":"605-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal insulin\u2010like growth factors and insulin\u2010like growth factor\u2010binding proteins for macrosomia prediction in diabetic and nondiabetic pregnancy: A prospective study"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-7924","authenticated-orcid":false,"given":"Elena N.","family":"Alekseenkova","sequence":"first","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine  St Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. N.","family":"Babakov","sequence":"additional","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA  St Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-7529","authenticated-orcid":false,"given":"S. A.","family":"Selkov","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine  St Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-240X","authenticated-orcid":false,"given":"G. C.","family":"Di\u00a0Renzo","sequence":"additional","affiliation":[{"name":"Centre for Reproductive and Perinatal Medicine University of Perugia  Perugia Italy"},{"name":"Wayne State University School of Medicine  Michigan Detroit USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-6900","authenticated-orcid":false,"given":"I. Yu.","family":"Kogan","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine  St Petersburg Russia"},{"name":"Department of Obstetrics, Gynecology and Reproduction St Petersburg State University  St Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-3032","authenticated-orcid":false,"given":"R. V.","family":"Kapustin","sequence":"additional","affiliation":[{"name":"D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine  St Petersburg Russia"},{"name":"Department of Obstetrics, Gynecology and Reproduction St Petersburg State University  St Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339910790909431"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1742271X17732807"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14047"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2021-0510"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1189"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02495.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00002"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"69","article-title":"Correlation of serum insulin like growth factor\u2010I with retinopathy in Malaysian pregnant diabetics","volume":"4","author":"Adzura S","year":"2011","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.017566"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-10-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-993893"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9914-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8569"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr067"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020633"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3296"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401522"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2015.11.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1134477"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.10.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.11.008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934093"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2013.07.004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0386"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2020.1838924"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98296-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.144"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2015.03.007"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T11:30:00Z","timestamp":1725017400000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ijgo.14696"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14696","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}