{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:03:43Z","timestamp":1777950223097,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness of prophylactic carbetocin with prophylactic oxytocin for preventing severe postpartum hemorrhage (PPH) following vaginal delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This before and after cohort study took place between 2020 and 2021 in a university maternity hospital. In 2021, the protocol for PPH prevention immediately after vaginal delivery changed: intravenous oxytocin (5\u00a0IU) was replaced by intravenous carbetocin (100\u2009\u03bcg). All patients with vaginal births were included, with two groups compared: patients who received prophylactic oxytocin in 2020 and those who received prophylactic carbetocin in 2021. The primary outcome was severe PPH, defined as one or more of the following: estimated blood loss \u22651500\u2009mL, transfusion \u22654\u00a0units of red blood cells, Bakri balloon use, embolization, vascular ligation, hysterectomy, and maternal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 4832 women included, 2417 received oxytocin and 2415 received carbetocin. The rate of severe PPH was similar in both groups (0.5% vs. 0.6%, respectively; adjusted odds ratio, 0.8 [95% confidence interval, 0.4\u20131.8]). The rate of PPH \u2265500\u2009mL was lower in the carbetocin group (4% vs. 5.8%; <jats:italic>P<\/jats:italic>\u00a0=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although prophylactic carbetocin was associated with a reduction in the rate of PPH \u2265500\u2009mL, carbetocin is no different to oxytocin in preventing severe PPH caused by atony after vaginal delivery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14743","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T07:54:55Z","timestamp":1677225295000},"page":"889-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effectiveness of prophylactic carbetocin versus oxytocin following vaginal delivery for preventing severe postpartum hemorrhage"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-8269","authenticated-orcid":false,"given":"Diane","family":"Korb","sequence":"first","affiliation":[{"name":"Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, INSERM, INRA Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Robert Debr\u00e9 Service de Gyn\u00e9cologie Obst\u00e9trique  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi","family":"Lopez","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, INSERM, INRA Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Laure","family":"H\u00f6rlin","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Robert Debr\u00e9 Service d'Anesth\u00e9sie R\u00e9animation  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, INSERM, INRA Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Robert Debr\u00e9 Service de Gyn\u00e9cologie Obst\u00e9trique  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance","family":"Borie","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, INSERM, INRA Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Sibony","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOP\u00e9, INSERM, INRA Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.09.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization.WHO recommendations uterotonics for the prevention of postpartum haemorrhage: Web annex 7: Choice of uterotonic agents.2018https:\/\/apps.who.int\/iris\/handle\/10665\/277283"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14305"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.04.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4806-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805489"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1011121"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16622"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1962841"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30659-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.12.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.11.319"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.14743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:16:05Z","timestamp":1699946165000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ijgo.14743"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14743","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,10]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}