{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:30:49Z","timestamp":1700008249202},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the diagnostic efficiency of a fluorescence colposcope with TMTP1\u2010PEG4\u2010ICG dye versus a conventional colposcope with acetic acid and Lugol's iodine in identifying cervical precancerous lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 218 women with abnormal cervical cancer screening results including cytology and\/or human papillomavirus (HPV) test were involved in the randomized controlled trial. Patients in the fluorescence colposcope group had TMTP1\u2010PEG4\u2010ICG dye applied to the cervix uteri before colposcopy. Patients in the conventional colposcope group were routinely administered acetic acid and Lugol's iodine to stain the cervix uteri. Two to four cervical sites per patient were taken out for biopsy. The diagnostic efficiency of fluorescence colposcopy and conventional colposcopy was calculated on a per\u2010patient and per\u2010site basis. \u03c7<jats:sup>2<\/jats:sup> test or Fisher exact test was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 194 patients and the corresponding 662 cervical sites were included in the final analysis. There was no statistically significant difference in the diagnostic efficiency between the two groups both on a per\u2010patient and a per\u2010site basis, including accuracy, sensitivity, specificity, positive predictive value, and negative predictive value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The fluorescence colposcope with TMTP1\u2010PEG4\u2010ICG dye was comparable to the conventional colposcope in identifying cervical precancerous lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14752","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T14:38:55Z","timestamp":1679323135000},"page":"969-976","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorescence colposcope with <scp>TMTP1\u2010PEG4\u2010ICG<\/scp> is comparable to the conventional colposcope in identifying cervical precancerous lesions: A randomized controlled 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanrong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohu","family":"Liu","sequence":"additional","affiliation":[{"name":"Britton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 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